盐酸厄洛替尼

Description

Erlotinib hydrochloride · CAS 183319-69-9 · C22H24ClN3O4. UNII DA87705X9K.

Identification

CAS Registry Number	183319-69-9
PubChem CID	176871
Molecular formula	C22H24ClN3O4
IUPAC name	N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine;hydrochloride
UNII (FDA)	DA87705X9K

Computed Descriptors

Molecular Weight	429.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	11
Exact Mass	429.1455339
Monoisotopic Mass	429.1455339
Topological Polar Surface Area	74.7
Heavy Atom Count	30
Formal Charge	0
Complexity	525

GHS Hazard Classification

Reported hazard statements	H302 (91.7%), H315 (16.7%), H317 (25%), H319 (16.7%), H351 (25%), H360 (25%), H361 (16.7%), H411 (50%)

Documented Uses

• Erlotinib hydrochloride is approved to be used alone or with other drugs to treat:
• • Non-small cell lung cancer (NSCLC) that is metastatic and has certain EGFR gene mutations. It may be used:
• • In patients on maintenance therapy or whose disease has gotten worse after treatment with chemotherapy.
• The use of erlotinib hydrochloride to treat NSCLC that does not have the EGFR gene mutations is no longer FDA-approved.
• • Pancreatic cancer. It is used with gemcitabine hydrochloride in patients whose cancer cannot be removed by surgery or has spread.
• Erlotinib hydrochloride is also being studied in the treatment of other types of cancer.

Synonyms

Erlotinib hydrochloride; 183319-69-9; erlotinib HCl; Tarceva; OSI-774; OSI 774; HCl, Erlotinib; CP-358,774-01; CP 358774; DA87705X9K; CP-358; CP-358774; CHEBI:53509; DTXSID10171412; CP-358774-01; NSC 718781

Frequently Asked Questions

What are the CAS number and molecular formula of Erlotinib hydrochloride?

CAS 183319-69-9; molecular formula C22H24ClN3O4; molecular weight — g/mol.

What other names is Erlotinib hydrochloride known by?

Erlotinib hydrochloride, 183319-69-9, erlotinib HCl, Tarceva, OSI-774, OSI 774.

Is Erlotinib hydrochloride classified as hazardous?

Hazard statements reported: H302, H315, H317, H319, H351.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.