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Home › Product Catalog › Erlotinib

Erlotinib

CAS 183321-74-6C22H23N3O4MW 393.4

Erlotinib (CAS No. 183321-74-6) is supplied by Jinan Shenghe Chemical Co., Ltd. with a typical purity of 按批次COA提供(不公开发布). Main applications include Pharmaceutical Intermediates & APIs. Bulk quantities are available with COA; purity and packaging are subject to batch COA and order confirmation.

Specifications

CAS Number183321-74-6
Molecular FormulaC22H23N3O4
Molecular Weight393.4
LogP2.7
Purity按批次COA提供(不公开发布)
Packaging按订单/批次确认(不公开发布)
ApplicationsPharmaceutical Intermediates & APIs
CategoryPharmaceutical Intermediates & APIs

Where it is used

Pharmaceutical Intermediates & APIs

Packaging & Supply

Packaging按订单/批次确认(不公开发布)
Purity按批次COA提供(不公开发布)
StorageSealed, cool and dry place
Lead TimeIn stock / per order

Documents & Support

COA provided with every batch; MSDS and technical documents available on request. Email us with product name and CAS number for a quote within one business day.

Frequently Asked Questions

What is the CAS number of Erlotinib?

The CAS number of Erlotinib is 183321-74-6.

What purity and packaging are available?

Typical purity is 按批次COA提供(不公开发布), supplied in 按订单/批次确认(不公开发布), with COA provided.

What are the applications of Erlotinib?

Main applications include Pharmaceutical Intermediates & APIs.

How do I buy Erlotinib or get a quote?

Email info@591daili.com or reach us on WhatsApp with the product name, CAS number and required quantity; quotes within one business day. Supplier: Jinan Shenghe Chemical Co., Ltd..

PubChem Public Data

Description

Erlotinib · CAS 183321-74-6 · C22H23N3O4. UNII J4T82NDH7E. Solubility: 8.91e-03 g/L; LogP: 2.7; LogP: 3.35.

Identification

CAS Registry Number183321-74-6
PubChem CID176870
Molecular formulaC22H23N3O4
IUPAC nameN-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
UNII (FDA)J4T82NDH7E

Computed Descriptors

Molecular Weight393.4
XLogP33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count11
Exact Mass393.16885622
Monoisotopic Mass393.16885622
Topological Polar Surface Area74.7
Heavy Atom Count29
Formal Charge0

Physical & Chemical Properties

Solubility8.91e-03 g/L
LogP2.7
LogP3.35

Physical description & handling notes

  • Solid
  • Very slightly soluble (hydrochloride salt - maximal solubility of approximately 0.4 mg/mL occurs at a pH of approximately 2)
  • MW: 429.90. MP: 228-230 °C. pKa (25 °C): 5.42. Solubility in water (pH approx 2): approximately 0.5 mg/mL. Slightly soluble in methanol. Practically insoluble in acetonitrile, acetone, ethyl acetate /Erlotinib hydrochloride/
  • Erlotinib Hydrochloride preparations (AHFS, 2012)
  • Table: Erlotinib Hydrochloride preparations [Table#8058]

GHS Hazard Classification

Reported hazard statementsH302 (35.7%), H351 (64.3%), H411 (14.3%), H413 (64.3%)

H302 (35.7%): Harmful if swallowed [Warning Acute toxicity, oral]

H351 (64.3%): Suspected of causing cancer [Warning Carcinogenicity]

Documented Uses

  • Use (kg; approx.) in Germany (2009): >100
  • Use (kg; exact) in Germany (2009): 129
  • Consumption (g per capita; approx.) in Germany (2009): 0.00122
  • Consumption (g per capita; exact) in Germany (2009): 0.00158
  • Preparation: R.C. Schnur, L.D. Arnold, WO 9630347; eidem, US 5747498 (1996, 1998 both to Pfizer)
  • Erlotinib is a first-generation receptor tyrosine kinase inhibitor (TKI) approved by the US Food and Drug Administration (FDA) for the treatment of certain types of non-small cell lung cancer (NSCLC) and advanced pancreatic cancer.

Synonyms

Erlotinib; 183321-74-6; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; 4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-; erlotinibum; DTXSID8046454; J4T82NDH7E; R-1415; RG-1415; DTXCID6026454; CP-35877401; CHEBI:114785; [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine; (6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl)-(3-ethynyl-phenyl)-amine; RefChem:5799; L01XE03

Frequently Asked Questions

What are the CAS number and molecular formula of Erlotinib?

CAS 183321-74-6; molecular formula C22H23N3O4; molecular weight — g/mol.

What other names is Erlotinib known by?

Erlotinib, 183321-74-6, N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine, 4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-, erlotinibum, DTXSID8046454.

Is Erlotinib classified as hazardous?

Hazard statements reported: H302, H351, H411, H413.

What are the key physical properties of Erlotinib?

Solubility: 8.91e-03 g/L; LogP: 2.7; LogP: 3.35.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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