雌莫司汀磷酸钠

Description

Estramustine sodium phosphate · CAS 52205-73-9 · C23H30Cl2NNa2O6P. UNII IQ856M1R16.

Identification

CAS Registry Number	52205-73-9
PubChem CID	444000
Molecular formula	C23H30Cl2NNa2O6P
IUPAC name	disodium;[(8R,9S,13S,14S,17S)-3-[bis(2-chloroethyl)carbamoyloxy]-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] phosphate
UNII (FDA)	IQ856M1R16

Computed Descriptors

Molecular Weight	564.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Exact Mass	563.0983186
Monoisotopic Mass	563.0983186
Topological Polar Surface Area	102
Heavy Atom Count	35
Formal Charge	0
Complexity	735

GHS Hazard Classification

Reported hazard statements	H351 (66.7%), H360 (66.7%), H361 (66.7%), H373 (33.3%)

Documented Uses

• A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA,

Synonyms

Estramustine phosphate sodium; 52205-73-9; Estramustine sodium phosphate; Estracyt; Estramustine phosphate disodium; DTXSID2048953; IQ856M1R16; Ro 21-8837/001; Estradiol 3-(bis(2-chloroethyl)carbamate) 17-(dihydrogen phosphate), disodium salt; DTXCID5028879; CHEBI:31562; Ro-218837-001; ESTRAMUSTINE PHOSPHATE SODIUM ANHYDROUS; Ro-21-8837/001; Estramustine 17-(dihydrogenphosphate) disodium salt anhydrous; Estramustine 17-(dihydrogenphosphate) disodium salt monohydrate

Frequently Asked Questions

What are the CAS number and molecular formula of Estramustine sodium phosphate?

CAS 52205-73-9; molecular formula C23H30Cl2NNa2O6P; molecular weight — g/mol.

What other names is Estramustine sodium phosphate known by?

Estramustine phosphate sodium, 52205-73-9, Estramustine sodium phosphate, Estracyt, Estramustine phosphate disodium, DTXSID2048953.

Is Estramustine sodium phosphate classified as hazardous?

Hazard statements reported: H351, H360, H361, H373.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.