Description
Efinaconazole · CAS 164650-44-6 · C18H22F2N4O. UNII J82SB7FXWB.
Identification
| CAS Registry Number | 164650-44-6 |
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| PubChem CID | 489181 |
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| Molecular formula | C18H22F2N4O |
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| IUPAC name | (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylidenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol |
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| UNII (FDA) | J82SB7FXWB |
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Computed Descriptors
| Molecular Weight | 348.4 |
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| XLogP3 | 2 |
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| Hydrogen Bond Donor Count | 1 |
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| Hydrogen Bond Acceptor Count | 6 |
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| Rotatable Bond Count | 5 |
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| Exact Mass | 348.17616766 |
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| Monoisotopic Mass | 348.17616766 |
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| Topological Polar Surface Area | 54.2 |
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| Heavy Atom Count | 25 |
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| Formal Charge | 0 |
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Physical description & handling notes
- mean ± SD plasma Cmax on Day 28 of treatment: 0.67 ± 0.37 ng/mL. mean ± SD AUC was 12.15 ± 6.91 ng*h/mL.
- For the topical treatment of onychomycosis, efinaconazole is commercially available as a 10% solution. The clear colorless to pale yellow solution contains efinaconazole in an alcohol-based vehicle. The topical solution also contains anhydrous citric acid, butylated hydroxytoluene, C12-15 alkyl lactate, cyclomethicone, diiospropyl adipate, disodium edetate, and purified water.
- Topical: Solution, 10%, (Jublia) Valeant.
GHS Hazard Classification
| Reported hazard statements | H361 (100%) |
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H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
P203, P280, P318, P405, and P501 (click each P-code to see the statement)
Documented Uses
- Indicated in the treatment of fungal infection of the nail, known as onychomycosis.
- Breast Feeding; Lactation; Anti-Infective Agents; Antifungal Agents;
- Jublia (efinaconazole) topical solution, 10% is an azole antifungal indicated for the topical treatment of onychomycosis of the toenail(s) due to Trichophyton rubrum and Trichophyton mentagrophytes. /Included in US product label/
- We sought to evaluate the efficacy of efinaconazole topical solution, 10%, in patients with onychomycosis and coexisting tinea pedis. We analyzed 1,655 patients, aged 18 to 70 years, randomized (3:1) to receive efinaconazole topical solution, 10%, or vehicle from two identical multicenter, double-blind, vehicle-controlled 48-week studies evaluating safety and efficacy. The primary end point was complete cure rate (0% clinical involvement of the target toenail and negative potassium hydroxide examination and fungal
- Onychomycosis is a common fungal infection of the nail unit that results in discoloration, subungual debris, thickening, onycholysis, and often pain and impairment of mobility. Dermatophytomas are characterized by a thick fungal mass within and under the nail plate and are especially resistant to treatment. Here we report a case of a patient with a dermatophytoma who had failed oral terbinafine but was successfully treated with efinaconazole 10% topical solution.
- Adverse effects reported in at least 1% of adults treated with efinaconazole 10% topical solution and more frequently than with topical vehicle solution include application site dermatitis, ingrown toenail, application site vesicles, and application site pain.
Synonyms
EFINACONAZOLE; 164650-44-6; (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; JUBLIA; KP-103; efinaconazol; Clenafin; KP103; Kp 103; efinaconazolum; IDP-108; J82SB7FXWB; CHEBI:82718; (2r,3r)-2-(2,4-difluorophenyl)-3-(4-methylidenepiperidin-1-yl)-1-(1h-1,2,4-triazol-1-yl)butan-2-ol; DTXSID40167787; (2R,3R)-2-(2,4-Difluorofenil)-3-(4-metilenopiperidin-1-il)-1-(1H-1,2,4-triazin-1-il)butan-2-ol
Frequently Asked Questions
What are the CAS number and molecular formula of Efinaconazole?
CAS 164650-44-6; molecular formula C18H22F2N4O; molecular weight — g/mol.
What other names is Efinaconazole known by?
EFINACONAZOLE, 164650-44-6, (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, JUBLIA, KP-103, efinaconazol.
Is Efinaconazole classified as hazardous?
Hazard statements reported: H361.
Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.
