半水雌二醇

Description

Estradiol hemihydrate · CAS 35380-71-3 · C36H50O5. UNII CXY7B3Q98Z. European Pharmacopoeia monograph.

Identification

CAS Registry Number	35380-71-3
PubChem CID	154274
Molecular formula	C36H50O5
IUPAC name	bis((8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol);hydrate
UNII (FDA)	CXY7B3Q98Z
Pharmacopoeial monograph	European Pharmacopoeia monograph

Computed Descriptors

Molecular Weight	562.8
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	0
Exact Mass	562.36582469
Monoisotopic Mass	562.36582469
Topological Polar Surface Area	81.9
Heavy Atom Count	41
Formal Charge	0
Complexity	382

GHS Hazard Classification

Reported hazard statements	H350 (21.6%), H351 (76.1%), H360 (79.5%), H362 (94.3%), H400 (19.3%), H410 (21.6%)

Documented Uses

• For the treatment of urogenital symptoms associated with post-menopausal atrophy of the vagina (such as dryness, burning, pruritus and dyspareunia) and/or the lower urinary tract (urinary urgency and dysuria).
• Breast Feeding; Lactation; Milk, Human; Estrogens; Hormones
• Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
• Exogenous estrogens are metabolized using the same mechanism as endogenous estrogens. Estrogens are partially metabolized by cytochrome P450. Route of Elimination: Estradiol, estrone and estriol are excreted in the urine along with glucuronide and sulfate conjugates. Half Life: 36 hours

Synonyms

ESTRADIOL HEMIHYDRATE; 35380-71-3; CXY7B3Q98Z; Estrasorb; MYFEMBREE COMPONENT ESTRADIOL HEMIHYDRATE; RefChem:55137; 17b-Estradiol; beta-Estradiol semihydrate; (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol;hydrate; Estrasorb (TN); beta-Estradiol hemihydrate; UNII-CXY7B3Q98Z; Estra-1,3,5(10)-triene-3,17beta-diol hydrate (2:1); Estradiol hemihydrate CRS; SCHEMBL37532; orb1744935

Frequently Asked Questions

What are the CAS number and molecular formula of Estradiol hemihydrate?

CAS 35380-71-3; molecular formula C36H50O5; molecular weight — g/mol.

What other names is Estradiol hemihydrate known by?

ESTRADIOL HEMIHYDRATE, 35380-71-3, CXY7B3Q98Z, Estrasorb, MYFEMBREE COMPONENT ESTRADIOL HEMIHYDRATE, RefChem:55137.

Is Estradiol hemihydrate classified as hazardous?

Hazard statements reported: H350, H351, H360, H362, H400.

Does Estradiol hemihydrate have a pharmacopoeial monograph?

Yes — a monograph exists in the European Pharmacopoeia (Ph. Eur.).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.