依福地平

Description

EFONIDIPINE · CAS 111011-63-3 · C34H38N3O7P. UNII 40ZTP2T37Q. Boiling Point: 746.9±60.0 °C.

Identification

CAS Registry Number	111011-63-3
PubChem CID	119171
Molecular formula	C34H38N3O7P
IUPAC name	2-(N-benzylanilino)ethyl 5-(5,5-dimethyl-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate
UNII (FDA)	40ZTP2T37Q

Computed Descriptors

Molecular Weight	631.7
XLogP3	5.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	10
Exact Mass	631.24473756
Monoisotopic Mass	631.24473756
Topological Polar Surface Area	123
Heavy Atom Count	45
Formal Charge	0

Physical & Chemical Properties

Boiling Point	746.9±60.0 °C

Physical description & handling notes

• poorly soluble

Documented Uses

• For the treatment of hypertension.
• Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
• A class of drugs that act by selective inhibition of calcium influx through cellular membranes.
• Agents that promote the excretion of urine through their effects on kidney function.
• Efonidipine is also referred to as NZ-105 and has been found to be mainly eliminated by the biliary system.
• The peak plasma concentration is attained at approximately 1.5 to 3.67 hours after ingestion. The half-life is measured to be about 4 hours.

Synonyms

Efonidipine; 111011-63-3; Efonidipino; DTXSID9043988; 40ZTP2T37Q; DTXCID7023988; efonidipinum; RefChem:590611; CHEBI:135859; Landel; Efonidipine [INN]; NCGC00182046-01; (+/-)-EFONIDIPINE; Efonidipine (INN); DB09235; C34H38N3O7P

Frequently Asked Questions

What are the CAS number and molecular formula of EFONIDIPINE?

CAS 111011-63-3; molecular formula C34H38N3O7P; molecular weight — g/mol.

What other names is EFONIDIPINE known by?

Efonidipine, 111011-63-3, Efonidipino, DTXSID9043988, 40ZTP2T37Q, DTXCID7023988.

What are the key physical properties of EFONIDIPINE?

Boiling Point: 746.9±60.0 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.