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Description

CYPROHEPTADINE HCl · CAS 969-33-5 · C21H22ClN. UNII 0S9323MCT0.

Identification

CAS Registry Number	969-33-5
PubChem CID	13770
Molecular formula	C21H22ClN
IUPAC name	1-methyl-4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine;hydrochloride
UNII (FDA)	0S9323MCT0

Computed Descriptors

Molecular Weight	323.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	0
Exact Mass	323.1440774
Monoisotopic Mass	323.1440774
Topological Polar Surface Area	3.2
Heavy Atom Count	23
Formal Charge	0
Complexity	423

Physical description & handling notes

• 171.7 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

GHS notification summary	1% (1 / 100)

GHS Hazard Classification

GHS notification summary	1% (1 / 100)
Reported hazard statements	H301 (46%), H302 (53%), H315 (99%), H319 (99%), H335 (97%), H361 (53%)

Documented Uses

• Used as an antihistaminic/anticholinergic and antiserotonergic agent. For treatment of perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis due to inhalant allergens and foods, mild uncomplicated allergic skin manifestations of urticaria and angioedema, amelioration of allergic reactions to blood or plasma, cold urticaria, dermatographism, and as therapy for anaphylactic reactions adjunctive to epinephrine.
• Agents, usually topical, that relieve itching (pruritus).
• Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.
• Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
• Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
• Hepatic (cytochrome P-450 system) and some renal. Route of Elimination: After a single 4 mg oral dose of14C-labelled cyproheptadine HCl in normal subjects, given as tablets 2% to 20% of the radioactivity was excreted in the stools. At least 40% of the administered radioactivity was excreted in the urine.

Synonyms

cyproheptadine hydrochloride; 969-33-5; Cyproheptadine Hcl; Peritol; Cyproheptadine hydrochloride anhydrous; Periactine; NSC-169911; Cyproheptadine Hydrochloride (anhydrous); 0S9323MCT0; NSC-759282; DTXSID5042586; CHEBI:59695; Cyproheptadine hydrocloride; NSC169911; CHEBI:650917; RefChem:57574

Frequently Asked Questions

What are the CAS number and molecular formula of CYPROHEPTADINE HCl?

CAS 969-33-5; molecular formula C21H22ClN; molecular weight — g/mol.

What other names is CYPROHEPTADINE HCl known by?

cyproheptadine hydrochloride, 969-33-5, Cyproheptadine Hcl, Peritol, Cyproheptadine hydrochloride anhydrous, Periactine.

Is CYPROHEPTADINE HCl classified as hazardous?

1% of GHS notifications report no hazard classification (1 of 100).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.