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Description

VENLAFAXINE HCL · CAS 99300-78-4 · C17H28ClNO2. UNII 7D7RX5A8MO.

Identification

CAS Registry Number	99300-78-4
PubChem CID	62923
Molecular formula	C17H28ClNO2
IUPAC name	1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol;hydrochloride
UNII (FDA)	7D7RX5A8MO

Computed Descriptors

Molecular Weight	313.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	313.1808568
Monoisotopic Mass	313.1808568
Topological Polar Surface Area	32.7
Heavy Atom Count	21
Formal Charge	0
Complexity	279

Regulatory Status

GHS notification summary	0.9% (1 / 113)

GHS Hazard Classification

GHS notification summary	0.9% (1 / 113)
Reported hazard statements	H302 (15.9%), H319 (88.5%)

Documented Uses

• For the management of major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder (social phobia), panic disorder with or without agoraphobia, vasomotor symptoms in women with breast cancer and in postmenopausal women, and neuropathic pain.
• Venlafaxine's toxicity appears to be higher than other SSRIs, with a fatal toxic dose closer to that of the tricyclic antidepressants than the SSRIs. Doses of 900 mg or more are likely to cause moderate toxicity. Deaths have been reported following large
• Drugs that selectively block or suppress the plasma membrane transport of SEROTONIN and NORADRENALINE into axon terminals and are used as ANTIDEPRESSIVE AGENTS.
• A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake.
• Norepinephrine Uptake Inhibitors [MoA]; Serotonin and Norepinephrine Reuptake Inhibitor [EPC]; Serotonin Uptake Inhibitors [MoA]
• Serotonin Uptake Inhibitors [MoA]; Serotonin and Norepinephrine Reuptake Inhibitor [EPC]; Norepinephrine Uptake Inhibitors [MoA]

Synonyms

Venlafaxine hydrochloride; 99300-78-4; VENLAFAXINE HCl; Effexor XR; Wy-45030; Vandral; Wy 45030; 1-(2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexanol hydrochloride; Wy-45,030; DTXSID8047397; 7D7RX5A8MO; 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride; NSC-745751; Venlafaxine (as hydrochloride); DTXCID6027397; Cyclohexanol, 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)-, hydrochloride

Frequently Asked Questions

What are the CAS number and molecular formula of VENLAFAXINE HCL?

CAS 99300-78-4; molecular formula C17H28ClNO2; molecular weight — g/mol.

What other names is VENLAFAXINE HCL known by?

Venlafaxine hydrochloride, 99300-78-4, VENLAFAXINE HCl, Effexor XR, Wy-45030, Vandral.

Is VENLAFAXINE HCL classified as hazardous?

0.9% of GHS notifications report no hazard classification (1 of 113).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.