Fenazaquin

Description

Fenazaquin · CAS 120928-09-8 · C20H22N2O. UNII DK5Q534WEE. Melting Point: 77.5-80 °C; Density: 1.16; Vapor Pressure: 3.4X10-3 mPa /2.55X10-8 mm Hg/ at 25 °C.

Identification

CAS Registry Number	120928-09-8
PubChem CID	86356
Molecular formula	C20H22N2O
IUPAC name	4-[2-(4-tert-butylphenyl)ethoxy]quinazoline
UNII (FDA)	DK5Q534WEE

Computed Descriptors

Molecular Weight	306.4
XLogP3	5.7
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	306.173213330
Monoisotopic Mass	306.173213330
Topological Polar Surface Area	35
Heavy Atom Count	23
Formal Charge	0

Physical & Chemical Properties

Melting Point	77.5-80 °C
Density	1.16
Vapor Pressure	3.4X10-3 mPa /2.55X10-8 mm Hg/ at 25 °C
LogP	log Kow = 5.51 at 20 °C
LogP	4.91
Dissociation Constants	pKa = 2.44

Physical description & handling notes

• Colorless crystals
• In acetone, hexane 33-50, acetone, ethyl acetate 400-500, n-chlorobutane, chloroform, toluene, N-methyl-2-pyrrolidone >500, dichloromethane >600, dimethylformamide 300-400, ethylene glycol <5, isopropanol, methanol 50-100 (all in g/L at 23 °C)
• In water, 0.102 mg/L (pH 5, 7) , 0.135 mg/L (pH 9); both at 20 °C
• DT50 of aqueous solution exposed to sunlight is 15 days (pH7, 25 °C)
• When heated to decomposition it emits toxic fumes of /nitrogen oxides/.
• Emulsifiable concentrate; suspension concentrate.

GHS Hazard Classification

Reported hazard statements	H301, H332, H400, H410

Documented Uses

• Fenazaquin is produced by reaction of 4-hydroxyquinazoline with phosphite and chlorine, and treating the resulting haloquinazoline with 4-tert-butylphenylethanol.
• The majority of usage is in Europe (>80%)
• Metabolism involved cleavage of the ether bond, with formation of the 4-hydroxyquinazoline and carboxylic acid derivatives. Other biotransformations included oxidation of one of the methyl groups on the alkyl side chain to produce either an alcohol, which was further metabolised by hydroxylation of the O-ether alkyl moiety, or a carboxylic acid, which was further metabolised by hydroxylation of the 2-position of the quinazoline ring.
• Fenazaquin is a miticide that exhibits both contact and ovicidal activity against a broad spectrum of mite and certain insects by inhibiting mitochondrial electron transport at the Complex I site (NADH-ubiquinone reductase).

Synonyms

Fenazaquin; 120928-09-8; Magister; 4-[2-(4-tert-butylphenyl)ethoxy]quinazoline; 4-tert-Butylphenethylquinazolin-4-yl ether; DTXSID4040476; DK5Q534WEE; 4-((4-(1,1-Dimethylethyl)phenyl)ethoxy)quinazoline; 4-tert-butylphenethyl quinazolin-4-yl ether; Quinazoline, 4-(2-(4-(1,1-dimethylethyl)phenyl)ethoxy)-; DTXCID2020476; CHEBI:38593; DE-436; EL-436; 4-(2-(4-(1,1-Dimethylethyl)phenyl)ethoxy)quinazoline; 4-(2-(4-tert-butylphenyl)ethoxy)quinazoline

Frequently Asked Questions

What are the CAS number and molecular formula of Fenazaquin?

CAS 120928-09-8; molecular formula C20H22N2O; molecular weight — g/mol.

What other names is Fenazaquin known by?

Fenazaquin, 120928-09-8, Magister, 4-[2-(4-tert-butylphenyl)ethoxy]quinazoline, 4-tert-Butylphenethylquinazolin-4-yl ether, DTXSID4040476.

Is Fenazaquin classified as hazardous?

Hazard statements reported: H301, H332, H400, H410.

What are the key physical properties of Fenazaquin?

Melting Point: 77.5-80 °C; Density: 1.16; Vapor Pressure: 3.4X10-3 mPa /2.55X10-8 mm Hg/ at 25 °C; LogP: log Kow = 5.51 at 20 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.