CAB（醋酸丁酸纤维素）

Description

CAB (cellulose acetate butyrate) · CAS 1264720-72-0 · C19H17F2N3O5. UNII HMH0132Z1Q.

Identification

CAS Registry Number	1264720-72-0
PubChem CID	54713659
Molecular formula	C19H17F2N3O5
IUPAC name	(3R,6S)-N-[(2,4-difluorophenyl)methyl]-10-hydroxy-6-methyl-8,11-dioxo-4-oxa-1,7-diazatricyclo[7.4.0.03,7]trideca-9,12-diene-12-carboxamide
UNII (FDA)	HMH0132Z1Q

Computed Descriptors

Molecular Weight	405.4
XLogP3	2.1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	3
Exact Mass	405.11362698
Monoisotopic Mass	405.11362698
Topological Polar Surface Area	99.2
Heavy Atom Count	29
Formal Charge	0

Physical description & handling notes

• Cabotegravir is an inhibitor of HIV integrase, which reduces viral replication. It has a long duration of action as the oral tablet is given daily and the intramuscular suspension is given monthly. Patients should be counselled regarding the risk of hypersensitivity, hepatotoxicity, and depression.

GHS Hazard Classification

Reported hazard statements	H400 (100%), H410 (100%)

Documented Uses

• Breast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Antiviral Agents; Anti-HIV Agents; Anti-Retroviral Agents; HIV Integrase Inhibitors
• Cabotegravir is a prescription medicine approved by the U.S. Food and Drug Administration (FDA). It is approved as two different dosage forms under two different brand names for the following uses:
• Cabotegravir oral tablet (brand name: Vocabria)For the short-term treatment of HIV in adults and adolescents 12 years of age and older who weigh at least 77 lb (35 kg) and who meet certain requirements, as determined by a health care provider. When used for HIV treatment, cabotegravir is always used with the HIV medicine rilpivirine (brand name: Edurant).
• For short-term PrEP to reduce the risk of getting HIV in adults and adolescents who weigh at least 77 lb (35 kg), are HIV negative, and are at risk of getting HIV from sex. Oral cabotegravir for PrEP should always be used in combination with safer sex practices, such as using condoms, to reduce the risk of getting other sexually transmitted infections.
• Long-acting injectable cabotegravir (brand name: Apretude)For HIV PrEP to reduce the risk of getting HIV in adults and adolescents who weigh at least 77 lb (35 kg), are HIV negative, and are at risk of getting HIV from sex. Long-acting injectable cabotegravir for PrEP should always be used in combination with safer sex practices, such as using condoms, to reduce the risk of getting other sexually transmitted infections.
• Vocabria (HIV treatment and pre-exposure prophylaxis [PrEP]), Apretude (HIV PrEP)

Synonyms

Cabotegravir; 1051375-10-0; GSK744; GSK1265744A; Apretude; GSK744 LAP; GSK744 LA; cabotegravirum; GSK-1265744A; S-265744; GSK 744; S/GSK1265744; HMH0132Z1Q; CHEBI:172944; CABENUVA COMPONENT CABOTEGRAVIR; RefChem:573195

Frequently Asked Questions

What are the CAS number and molecular formula of CAB (cellulose acetate butyrate)?

CAS 1264720-72-0; molecular formula C19H17F2N3O5; molecular weight — g/mol.

What other names is CAB (cellulose acetate butyrate) known by?

Cabotegravir, 1051375-10-0, GSK744, GSK1265744A, Apretude, GSK744 LAP.

Is CAB (cellulose acetate butyrate) classified as hazardous?

Hazard statements reported: H400, H410.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.