Phenylephrine

Description

Phenylephrine · CAS 1228015-39-1 · C9H13NO2. UNII 1WS297W6MV. Melting Point: 140-145 °C; Melting Point: 169-172 °C; LogP: -0.31.

Identification

CAS Registry Number	1228015-39-1
PubChem CID	6041
Molecular formula	C9H13NO2
IUPAC name	3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol
UNII (FDA)	1WS297W6MV

Computed Descriptors

Molecular Weight	167.20
XLogP3	-0.3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	167.094628657
Monoisotopic Mass	167.094628657
Topological Polar Surface Area	52.5
Heavy Atom Count	12
Formal Charge	0

Physical & Chemical Properties

Melting Point	140-145 °C
Melting Point	169-172 °C
LogP	-0.31
Dissociation Constants	8.97
Dissociation Constants	pKa = 8.97

Physical description & handling notes

• Solid
• Freely soluble in water
• FREELY SOL IN GLYCERIN /PHENYLEPHRINE HYDROCHLORIDE/
• Solutions of phenylephrine hydrochloride that have been diluted in 5% dextrose injection are stable for at least 48 hours at pH 3.5-7.5. /Phenylephrine hydrochloride/
• Prolonged exposure to air or strong light may cause oxidation and discoloration.
• 138.7 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID3021142]

GHS Hazard Classification

Reported hazard statements	H302 (100%)

Documented Uses

• Sympathomimetic vasoconstructor amine ... used for nasal congestion /Hydrochloride/
• ... used to dilate the pupil both for ophthalmoscopy in the treatment of uveitis and for cataract surgery /Hydrochloride/
• THERAP CAT: Mydriatic; decongestant; in treatment of fecal incontinence.
• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• REACTION OF M-HYDROXYPHENACYL BROMIDE WITH METHYLAMINE FOLLOWED BY CATALYTIC HYDROGENATION, THEN DISSOLUTION IN ETHER, AND TREATMENT WITH HYDROGEN CHLORIDE

Synonyms

phenylephrine; 59-42-7; Metasynephrine; m-Oxedrine; Mezaton; m-Sympatol; Metasympatol; Mesatone; m-Sympathol; m-Synephrine; Metaoxedrine; Metaoxedrin; Visadron; Mesaton; Isophrin; Fenilefrina

Frequently Asked Questions

What are the CAS number and molecular formula of Phenylephrine?

CAS 1228015-39-1; molecular formula C9H13NO2; molecular weight — g/mol.

What other names is Phenylephrine known by?

phenylephrine, 59-42-7, Metasynephrine, m-Oxedrine, Mezaton, m-Sympatol.

Is Phenylephrine classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of Phenylephrine?

Melting Point: 140-145 °C; Melting Point: 169-172 °C; LogP: -0.31; Dissociation Constants: 8.97.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.