5-氨基水杨酸

Description

5-Aminosalicylic acid · CAS 89-57-6 · C7H7NO3. UNII 4Q81I59GXC. Melting Point: 260-280 °C; Melting Point: 283 °C; Solubility: 0.84.

Identification

CAS Registry Number	89-57-6
PubChem CID	4075
Molecular formula	C7H7NO3
IUPAC name	5-amino-2-hydroxybenzoic acid
UNII (FDA)	4Q81I59GXC

Computed Descriptors

Molecular Weight	153.14
XLogP3	1.3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Exact Mass	153.042593085
Monoisotopic Mass	153.042593085
Topological Polar Surface Area	83.6
Heavy Atom Count	11
Formal Charge	0

Physical & Chemical Properties

Melting Point	260-280 °C
Melting Point	283 °C
Solubility	0.84
Solubility	1.22e+01 g/L
Vapor Pressure	0.00000006 [mmHg]
LogP	1.2
LogP	0.48

Physical description & handling notes

• 5-aminosalicylic acid appears as odorless white to pinkish crystals or purplish-tan powder. Aqueous solutions acidic (pH approximately 4.1 at 0.8 mg/L water). (NTP, 1992)
• White to pinkish solid; [Merck Index] Purplish tan solid; [NTP] Powder; [Alfa Aesar MSDS]
• Solid
• White to pinkish crystals
• 536 °F (decomposes) (NTP, 1992)
• less than 1 mg/mL at 70 °F (NTP, 1992)

Regulatory Status

GHS notification summary	0.5% (1 / 195)

GHS Hazard Classification

GHS notification summary	0.5% (1 / 195)
Reported hazard statements	H315 (81.5%), H317 (44.1%), H319 (81.5%), H335 (81%), H412 (17.9%)

Documented Uses

• Used to make dyes and light-sensitive paper; Also used as a gastrointestinal anti-inflammatory drug; [Merck Index] A metabolite of the drug sulfasalazine; [REPROTOX]
• In manufacture of light-sensitive paper, azo and sulfur dyes
• Treatment of ulcerative colitis (England)
• It is used orally, in a delay-release formulation, as a retention enema, and as a suppository.
• THERAP CAT: Anti-inflammatory (gastrointestinal)
• Synthetic Polymer MALDI Matrix Compounds

Synonyms

5-Aminosalicylic acid; mesalamine; 89-57-6; Mesalazine; 5-Amino-2-hydroxybenzoic acid; 5-ASA; Fisalamine; Lialda; m-Aminosalicylic acid; Benzoic acid, 5-amino-2-hydroxy-; Mesalazina; sfRowasa; Apriso; p-Aminosalicylsaeure; Asacolitin; Mesalazinum

Frequently Asked Questions

What are the CAS number and molecular formula of 5-Aminosalicylic acid?

CAS 89-57-6; molecular formula C7H7NO3; molecular weight — g/mol.

What other names is 5-Aminosalicylic acid known by?

5-Aminosalicylic acid, mesalamine, 89-57-6, Mesalazine, 5-Amino-2-hydroxybenzoic acid, 5-ASA.

Is 5-Aminosalicylic acid classified as hazardous?

0.5% of GHS notifications report no hazard classification (1 of 195).

What are the key physical properties of 5-Aminosalicylic acid?

Melting Point: 260-280 °C; Melting Point: 283 °C; Solubility: 0.84; Solubility: 1.22e+01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.