Fluticasone propionate

Description

Fluticasone propionate · CAS 80474-14-2 · C25H31F3O5S. UNII O2GMZ0LF5W. Melting Point: 261-273 °C; LogP: 2.78.

Identification

CAS Registry Number	80474-14-2
PubChem CID	444036
Molecular formula	C25H31F3O5S
IUPAC name	[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
UNII (FDA)	O2GMZ0LF5W

Computed Descriptors

Molecular Weight	500.6
XLogP3	4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	6
Exact Mass	500.18442974
Monoisotopic Mass	500.18442974
Topological Polar Surface Area	106
Heavy Atom Count	34
Formal Charge	0

Physical & Chemical Properties

Melting Point	261-273 °C
LogP	2.78

Physical description & handling notes

• Solid
• Insoluble
• Systemically, fluticasone propionate activates glucocorticoid receptors, and inhibits lung eosinophilia in rats. Fluticasone propionate as a topical formulation is also associated with vasoconstriction in the skin.

Regulatory Status

GHS notification summary	10% (2 / 20)

GHS Hazard Classification

GHS notification summary	10% (2 / 20)
Reported hazard statements	H302 (20%), H317 (10%), H334 (10%), H360 (45%), H361 (35%), H373 (65%), H410 (15%), H413 (20%)

Documented Uses

• Fluticasone propionate is indicated as an inhaler for the treatment and management of asthma by prophylaxisas well as inflammatory and pruritic dermatoses. Fluticasone propionate nasal spray is indicated for managing allergic and nonallergic rhinitis.
• Substances that reduce or suppress INFLAMMATION.
• Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
• Drugs used to treat or prevent skin disorders or for the routine care of skin.
• Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
• Corticosteroid Hormone Receptor Agonists [MoA]; Corticosteroid [EPC]

Synonyms

FLUTICASONE PROPIONATE; 80474-14-2; Flovent; Cutivate; Flixotide; Flonase; Flovent HFA; Flovent Diskus; Flovent Diskus 50; Flovent Diskus 100; Flovent Diskus 250; Xhance; CCI-18781; ArmonAir RespiClick; CCI 18781; DTXSID8045511

Frequently Asked Questions

What are the CAS number and molecular formula of Fluticasone propionate?

CAS 80474-14-2; molecular formula C25H31F3O5S; molecular weight — g/mol.

What other names is Fluticasone propionate known by?

FLUTICASONE PROPIONATE, 80474-14-2, Flovent, Cutivate, Flixotide, Flonase.

Is Fluticasone propionate classified as hazardous?

10% of GHS notifications report no hazard classification (2 of 20).

What are the key physical properties of Fluticasone propionate?

Melting Point: 261-273 °C; LogP: 2.78.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.