indapamide

Description

indapamide · CAS 26807-65-8 · C16H16ClN3O3S. UNII F089I0511L. Melting Point: 160-162; Melting Point: 161 °C; Solubility: 3.42e-02 g/L.

Identification

CAS Registry Number	26807-65-8
PubChem CID	3702
Molecular formula	C16H16ClN3O3S
IUPAC name	4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoylbenzamide
UNII (FDA)	F089I0511L

Computed Descriptors

Molecular Weight	365.8
XLogP3	2.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	365.0600902
Monoisotopic Mass	365.0600902
Topological Polar Surface Area	101
Heavy Atom Count	24
Formal Charge	0

Physical & Chemical Properties

Melting Point	160-162
Melting Point	161 °C
Solubility	3.42e-02 g/L
LogP	2.2
LogP	1.83
Dissociation Constants	8.8

Physical description & handling notes

• Solid
• >54.9 [ug/mL] (The mean of the results at pH 7.4)
• 195.9 Ų [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID7044633]
• 186.6 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID7044633]
• 187.6 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID7044633]
• 184.6 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

GHS notification summary	1.5% (1 / 68)

GHS Hazard Classification

GHS notification summary	1.5% (1 / 68)
Reported hazard statements	H361 (86.8%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >50
• Consumption (g per capita; approx.) in Germany (2009): 0.000611
• Consumption (g per capita) in the USA (2002): 0.000159
• Indapamide is a diuretic indicated for use as monotherapy or in combination with other blood pressure-lowering agents to treat hypertension. It may also be used to treat fluid and salt retention associated with congestive heart failure.
• Breast Feeding; Lactation; Milk, Human; Antihypertensive Agents; Thiazide Diuretics
• Medicines used in heart failure

Synonyms

indapamide; 26807-65-8; Indamol; Veroxil; Lozol; Fludex; Indaflex; Ipamix; Noranat; Tandix; Bajaten; Natrilix; Tertensif; Arifon; Damide; Indapamida

Frequently Asked Questions

What are the CAS number and molecular formula of indapamide?

CAS 26807-65-8; molecular formula C16H16ClN3O3S; molecular weight — g/mol.

What other names is indapamide known by?

indapamide, 26807-65-8, Indamol, Veroxil, Lozol, Fludex.

Is indapamide classified as hazardous?

1.5% of GHS notifications report no hazard classification (1 of 68).

What are the key physical properties of indapamide?

Melting Point: 160-162; Melting Point: 161 °C; Solubility: 3.42e-02 g/L; LogP: 2.2.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.