山柰酚

Description

Kaempferol · CAS 520-18-3 · C15H10O6. UNII 731P2LE49E. Melting Point: 277; Melting Point: 277 °C; Melting Point: 285 - 287 °C.

Identification

CAS Registry Number	520-18-3
PubChem CID	5280863
Molecular formula	C15H10O6
IUPAC name	3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one
UNII (FDA)	731P2LE49E

Computed Descriptors

Molecular Weight	286.24
XLogP3	1.9
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	1
Exact Mass	286.04773803
Monoisotopic Mass	286.04773803
Topological Polar Surface Area	107
Heavy Atom Count	21
Formal Charge	0

Physical & Chemical Properties

Melting Point	277
Melting Point	277 °C
Melting Point	285 - 287 °C
LogP	3.39
Collision Cross Section	186 Ų [M+Na]+
Collision Cross Section	164.9 Ų [M+H]+
Collision Cross Section	165.4 Ų [M-H]-

Physical description & handling notes

• Solid
• Yellow needles from alcohol and water
• MP: 276-278 °C and 278-280 °C decomposes
• Soluble in hot alcohol, ether or alkalies
• Insoluble in benzene; slightly soluble in chloroform; soluble in acetic acid, alkalies; very soluble in ethanol, ethyl ether, acetone
• When heated to decomposition it emits acrid smoke and fumes.

Regulatory Status

GHS notification summary	1.3% (1 / 77)

GHS Hazard Classification

GHS notification summary	1.3% (1 / 77)
Reported hazard statements	H301 (89.6%), H341 (90.9%)

Documented Uses

• Antioxidants useful in cosmetics. /From table/
• Kaempferol is a natural flavonoid which has been isolated from Delphinium, Witch-hazel, grapefruit, and other plant sources.
• /EXPL/ Despite recent advances in understanding molecular mechanisms involved in glioblastoma progression, the prognosis of the most malignant brain tumor continues to be dismal. Because the flavonoid kaempferol is known to suppress growth of a number of human malignancies, we investigated the effect of kaempferol on human glioblastoma cells. Kaempferol induced apoptosis in glioma cells by elevating intracellular oxidative stress. Heightened oxidative stress was characterized by an increased generation of reactive
• Kaempferol is a flavonoid widely distributed in edible plants and has been shown to be genotoxic to V79 cells in the absence of external metabolizing systems. The presence of an external metabolizing system, such as rat liver homogenates (S9 mix), leads to an increase in its genotoxicity, which is attributed to its biotransformation to the more genotoxic flavonoid quercetin, via the cytochrome P450 (CYP) mono-oxygenase system. ...
• Kaempferol has known human metabolites that include Kaempferol-3-glucuronide and (2S,3S,4S,5R)-6-[3,5-Dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid.
• Kaempferol is a known human metabolite of kaempferide and galangin.

Synonyms

kaempferol; 520-18-3; Kaempherol; Robigenin; Rhamnolutein; Populnetin; Trifolitin; Indigo Yellow; Pelargidenolon; Rhamnolutin; Kempferol; Swartziol; 3,4',5,7-Tetrahydroxyflavone; Nimbecetin; 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; Campherol

Frequently Asked Questions

What are the CAS number and molecular formula of Kaempferol?

CAS 520-18-3; molecular formula C15H10O6; molecular weight — g/mol.

What other names is Kaempferol known by?

kaempferol, 520-18-3, Kaempherol, Robigenin, Rhamnolutein, Populnetin.

Is Kaempferol classified as hazardous?

1.3% of GHS notifications report no hazard classification (1 of 77).

What are the key physical properties of Kaempferol?

Melting Point: 277; Melting Point: 277 °C; Melting Point: 285 - 287 °C; LogP: 3.39.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.