Methylthioninium Chloride

Description

Methylthioninium Chloride · CAS 61-73-4 · C16H18N3S.Cl. UNII 8NAP7826UB. Melting Point: 100; Melting Point: 100-110 °C (decomposes); Solubility: In water, 43,600 mg/L at 25 °C..

Identification

CAS Registry Number	61-73-4
PubChem CID	6099
Molecular formula	C16H18N3S.Cl
IUPAC name	[7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium chloride
UNII (FDA)	8NAP7826UB

Computed Descriptors

Molecular Weight	319.9
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Exact Mass	319.0909965
Monoisotopic Mass	319.0909965
Topological Polar Surface Area	43.9
Heavy Atom Count	21
Formal Charge	0
Complexity	483

Physical & Chemical Properties

Melting Point	100
Melting Point	100-110 °C (decomposes)
Solubility	In water, 43,600 mg/L at 25 °C.
Vapor Pressure	0.00000013 [mmHg]
Color Additive Status	81.30

Physical description & handling notes

• Dark green crystals or powder with a bronze-like luster; Solutions in water or alcohol are deep blue; [ChemIDplus]
• Dark green crystals or powder from chloroform-ethyl ether
• Solutions have a deep blue color /Methylene blue zinc-free dye/
• Slight odor
• Soluble in water
• Soluble in ethanol, chloroform; slightly soluble in pyridine; insoluble in ethyl ether

Regulatory Status

Regulatory & Food Contact	FDA Cumulative Estimated Daily Intake (CEDI): FCS FDA Inventory of Food Contact Substances Listed in 21 CFR: FCS CIR / INCI: Hair dyeing
GHS notification summary	8.1% (22 / 273)

GHS Hazard Classification

GHS notification summary	8.1% (22 / 273)
Reported hazard statements	H302 (91.6%), H318 (25.6%), H412 (10.3%), H361, H370, H372

Documented Uses

• Used as a stain in bacteriology, a chemical reagent, an antimethemoglobinemic drug, a polymerization inhibitor, and a temporary hair colorant; also used as a paper, textile, and leather dye; [HSDB] Azine dye; [Kirk-Othmer]
• Pulp and Paper Processing [Category: Industry]
• Textiles (Printing, Dyeing, or Finishing) [Category: Industry]
• Stain in bacteriology; reagent for several chemicals; as mixed indicator; as redox colorimetric agent. Targeting agent for melanoma.
• Dyeing cotton and wool, biological and bacteriological stains, reagent in oxidation-reduction titrations in volumetric analysis, indicator
• Methylene blue is mainly used to dye paper and office supplies, but also to tone up silk colors. ... as a stain in microscopy, as a hydrogen acceptor in enzymatic dehydrogenations, as a redox indicator in iodometry and titanometry, and as a cosmetic dye.

Synonyms

methylene blue; 61-73-4; Basic blue 9; Methylthioninium chloride; Solvent blue 8; Swiss Blue; C.I. Basic Blue 9; Chromosmon; Methylene Blue anhydrous; Methylene Blue N; Methylene Blue BB; Urolene blue; Methylenium ceruleum; Methylene Blue chloride; Bleu de methylene; Methylene Blue A

Frequently Asked Questions

What are the CAS number and molecular formula of Methylthioninium Chloride?

CAS 61-73-4; molecular formula C16H18N3S.Cl; molecular weight — g/mol.

What other names is Methylthioninium Chloride known by?

methylene blue, 61-73-4, Basic blue 9, Methylthioninium chloride, Solvent blue 8, Swiss Blue.

What is the regulatory status of Methylthioninium Chloride?

Documented regulatory listings: FDA Cumulative Estimated Daily Intake (CEDI): FCS; FDA Inventory of Food Contact Substances Listed in 21 CFR: FCS; CIR / INCI: Hair dyeing.

Is Methylthioninium Chloride classified as hazardous?

8.1% of GHS notifications report no hazard classification (22 of 273).

What are the key physical properties of Methylthioninium Chloride?

Melting Point: 100; Melting Point: 100-110 °C (decomposes); Solubility: In water, 43,600 mg/L at 25 °C.; Vapor Pressure: 0.00000013 [mmHg].

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.