Nifedipine

Description

Nifedipine · CAS 21829-25-4 · C17H18N2O6. UNII I9ZF7L6G2L. Melting Point: 342 to 345 °F (NTP, 1992); Melting Point: 172-174 °C; Melting Point: 172 - 174 °C.

Identification

CAS Registry Number	21829-25-4
PubChem CID	4485
Molecular formula	C17H18N2O6
IUPAC name	dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
UNII (FDA)	I9ZF7L6G2L

Computed Descriptors

Molecular Weight	346.3
XLogP3	2.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	346.11648630
Monoisotopic Mass	346.11648630
Topological Polar Surface Area	110
Heavy Atom Count	25
Formal Charge	0

Physical & Chemical Properties

Melting Point	342 to 345 °F (NTP, 1992)
Melting Point	172-174 °C
Melting Point	172 - 174 °C
Solubility	1.77e-02 g/L
Vapor Pressure	2.6X10-8 mm Hg at 25 °C
LogP	2.2
LogP	log Kow = 2.20
LogP	2.06
Formulations/Preparations	Bay 1040
Formulations/Preparations	Bay A 1040

Physical description & handling notes

• Nifedipine appears as odorless yellow crystals or powder. Tasteless. (NTP, 1992)
• Solid
• Yellow crystals
• less than 1 mg/mL at 67.1 °F (NTP, 1992)
• Insoluble
• Solubility at 20 °C (g/L): acetone 250, methylene chloride 160, chloroform 140, ethyl acetate 50, methanol 26, ethanol 17

GHS Hazard Classification

Reported hazard statements	H302 (98.3%), H361 (25.8%)

Documented Uses

• Therapeutic Category: Antianginal; antihypertensive.
• Use (kg; approx.) in Germany (2009): >2500
• Consumption (g per capita; approx.) in Germany (2009): 0.0305
• Consumption (g per capita) in the USA (2002): 0.0468
• Heating 2-nitrobenzaldehyde with an excess of methyl acetoacetate and ammonia in methanol for several hours affords nifedipine as light-sensitive yellow crystals in high yield.
• Preparation: Bossert, Vater, ZA 6801482; eidem, US 3485847 (1968, 1969 both to Bayer)

Synonyms

nifedipine; 21829-25-4; Procardia; Adalat; Procardia XL; Citilat; Oxcord; Adalat CC; Fenihidine; dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; Bay-a-1040; Coracten; Afeditab CR; Nifedipino; Nifedipinum; Adipine XL

Frequently Asked Questions

What are the CAS number and molecular formula of Nifedipine?

CAS 21829-25-4; molecular formula C17H18N2O6; molecular weight — g/mol.

What other names is Nifedipine known by?

nifedipine, 21829-25-4, Procardia, Adalat, Procardia XL, Citilat.

Is Nifedipine classified as hazardous?

Hazard statements reported: H302, H361.

What are the key physical properties of Nifedipine?

Melting Point: 342 to 345 °F (NTP, 1992); Melting Point: 172-174 °C; Melting Point: 172 - 174 °C; Solubility: 1.77e-02 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.