nystatin dihydrate

Description

nystatin dihydrate · CAS 1400-61-9 · C47H75NO17. UNII HMS5080P05. Melting Point: 160; Solubility: 360; Solubility: In water, 3.60X10+2 mg/L at 24 °C.

Identification

CAS Registry Number	1400-61-9
PubChem CID	4568
Molecular formula	C47H75NO17
IUPAC name	33-(4-amino-3,5-dihydroxy-6-methyloxan-2-yl)oxy-1,3,4,7,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid
UNII (FDA)	HMS5080P05

Computed Descriptors

Molecular Weight	926.1
XLogP3	-0.2
Hydrogen Bond Donor Count	12
Hydrogen Bond Acceptor Count	18
Rotatable Bond Count	3
Exact Mass	925.50349992
Monoisotopic Mass	925.50349992
Topological Polar Surface Area	320
Heavy Atom Count	65
Formal Charge	0

Physical & Chemical Properties

Melting Point	160
Solubility	360
Solubility	In water, 3.60X10+2 mg/L at 24 °C
LogP	0.5

Physical description & handling notes

• Light yellow powder
• Yellow to tan powder
• Odor suggestive of cereals
• Gradually decomp above 160 °C without melting by 250 °C
• MW: 926.12 /Form not specified/
• Mg/ml at about 28 °C: methanol 11.2, ethanol 1.2, chloroform 0.48, carbon tetrachloride 1.23, benzene 0.28, toluene 0.285, acetone 0.390, ethyl acetate 0.75, ethylene glycol 8.75

Regulatory Status

Regulatory & Food Contact	ANTIFUNGAL_AGENT: Veterinary Drug Nystatin in poorly absorbed from the gut and only causes occasional gastrointestinal symptoms (nausea) in huma NMRS 45/TRS 430-JECFA 12/25
GHS notification summary	75% (6 / 8)

GHS Hazard Classification

GHS notification summary	75% (6 / 8)
Reported hazard statements	H300 (12.5%), H335 (12.5%), H372 (12.5%)

Documented Uses

• An experimental teratogen. An anti-biotic
• Antimycotic polyene antibiotic... for local treatment of vulvovaginal candidiasis (monoliasis).
• Medicine (antifungal antibiotics), feed additive
• Use (kg; approx.) in Germany (2009): >7500
• Consumption (g per capita; approx.) in Germany (2009): 0.0916
• Consumption (g per capita) in the USA (2002): 0.000886

Synonyms

RefChem:1068860; DTXCID40809796; DTXSID00859636; nystatin; 1400-61-9; ISO-Nystatin; Nystatin powder; Nystatin, >70% A3; SCHEMBL5008933; HMS5080P05; FN177277; NS00000545

Frequently Asked Questions

What are the CAS number and molecular formula of nystatin dihydrate?

CAS 1400-61-9; molecular formula C47H75NO17; molecular weight — g/mol.

What other names is nystatin dihydrate known by?

RefChem:1068860, DTXCID40809796, DTXSID00859636, nystatin, 1400-61-9, ISO-Nystatin.

What is the regulatory status of nystatin dihydrate?

Documented regulatory listings: ANTIFUNGAL_AGENT: Veterinary Drug; Nystatin in poorly absorbed from the gut and only causes occasional gastrointestinal symptoms (nausea) in huma; NMRS 45/TRS 430-JECFA 12/25.

Is nystatin dihydrate classified as hazardous?

75% of GHS notifications report no hazard classification (6 of 8).

What are the key physical properties of nystatin dihydrate?

Melting Point: 160; Solubility: 360; Solubility: In water, 3.60X10+2 mg/L at 24 °C; LogP: 0.5.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.