rifampicin

Description

rifampicin · CAS 13292-46-1 · C43H58N4O12. UNII VJT6J7R4TR. Melting Point: 183; Melting Point: Decomposes 183-188 °C; Solubility: 1400.

Identification

CAS Registry Number	13292-46-1
PubChem CID	135398735
Molecular formula	C43H58N4O12
IUPAC name	[(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate
UNII (FDA)	VJT6J7R4TR

Computed Descriptors

Molecular Weight	822.9
XLogP3	4.9
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	15
Rotatable Bond Count	5
Exact Mass	822.40512330
Monoisotopic Mass	822.40512330
Topological Polar Surface Area	220
Heavy Atom Count	59
Formal Charge	0

Physical & Chemical Properties

Melting Point	183
Melting Point	Decomposes 183-188 °C
Solubility	1400
Solubility	In water, 1,400 mg/L at 25 °C
LogP	2.7
Dissociation Constants	1.7

Physical description & handling notes

• Red to orange platelets from acetone
• Red-brown crystalline powder
• ODORLESS
• Freely sol in methyl chloride, dimethyl sulfoxide; sol in tetrahydrofuran; slightly sol in water (pH less than 6), acetone, carbon tetrachloride
• Freely soluble in chloroform, soluble in ethyl acetate and in methanol.
• 3.1X10-34 mm Hg at 25 °C /Estimated/

GHS Hazard Classification

Reported hazard statements	H302 (98.4%), H315 (85.2%), H319 (85.2%), H335 (83.6%)

Documented Uses

• Antibacterial (tuberculostatic)
• Use (kg; approx.) in Germany (2009): >1000
• Use (kg) in France (2004): 2383
• Consumption (g per capita; approx.) in Germany (2009): 0.0122
• Consumption (g per capita) in France (2004): 0.0394
• For the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections.

Synonyms

Rifampicin; rifampin; 13292-46-1; Rifaldazine; Rifamycin AMP; Rifaprodin; Rifoldin; Rifa; Rifampicinum; Riforal; Abrifam; Eremfat; L-5103 Lepetit; Rifaldin; Rifoldine; R/AMP

Frequently Asked Questions

What are the CAS number and molecular formula of rifampicin?

CAS 13292-46-1; molecular formula C43H58N4O12; molecular weight — g/mol.

What other names is rifampicin known by?

Rifampicin, rifampin, 13292-46-1, Rifaldazine, Rifamycin AMP, Rifaprodin.

Is rifampicin classified as hazardous?

Hazard statements reported: H302, H315, H319, H335.

What are the key physical properties of rifampicin?

Melting Point: 183; Melting Point: Decomposes 183-188 °C; Solubility: 1400; Solubility: In water, 1,400 mg/L at 25 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.