硫酸长春碱

硫酸长春碱（CAS 143-67-9）的公开数据库记录，列此仅供独立核对。

物理形态与操作说明

• Solvated needles from methanol
• Negligible
• ODORLESS & HYGROSCOPIC; WHITE TO SLIGHTLY YELLOW, AMORPHOUS OR CRYSTALLINE POWDER; FREELY SOL IN WATER /VINBLASTINE SULFATE/
• Practically insoluble in water, petroleum ether; soluble in alcohols, acetone, ethyl acetate, chloroform
• SOLN MAY BE STORED IN REFRIGERATOR FOR PERIODS OF 30 DAYS WITHOUT SIGNIFICANT LOSS OF POTENCY /VINBLASTINE SULFATE/
• Crystallizes as hydrate, mp 284-285 °C. Specific optical rotation = - 28 deg at 26 °C/D ( c = 1.01 in methanol); UV max (Methanol): 212, 262, 282, 292 nm (log epsilon = 4.75, 4.28, 4.22, 4,18). Very slightly soluble in ethanol. Practically insoluble in ether. One part is soluble in 10 parts of water, 50 parts of chloroform /Sulfate/

公开数据库收录的理化数据

这个物质在各数据库里的编号

数据库记载的用途

• For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
• ... in the treatment of Hodgkins disease /Vinblastine sulfate USP/
• ... Isolated from periwinkle, Vinca rosea Linn, Apocynaceae.
• BY EXTRACTING LEAVES, BARK, OR STEMS OF VINCA ROSEA ... ISOLATING ALKALOID ... BY PRECIPITATION & SOLVENT TECHNIQUES, & PURIFYING BY CHROMATOGRAPHY ... CONVERSION TO (1:1) SULFATE ... BY DISSOLVING ALKALOID IN EQUIMOLAR QUANTITY OF DILUTE SULFURIC ACID & ... EVAPORATING TO DRYNESS OR PRECIPITATING WITH SUITABLE ORG SOLVENT. /VINBLASTINE SULFATE/
• Vinblastine and vincristine occur in Catharanthus roseus (L). The plant contains only very small amounts of vinblastine and vincristine, and their isolation is correspondingly difficult. First the alkaloids present are separated by extraction into alkaloid tartrate soluble in benzene and alkaloid tartrates insoluble in benzene. Vinblastine and vincristine belong to the first group. They then are separated by chromatography on aluminum oxide deactivated with acetic acid.
• VINBLASTINE IS CLASS II IMMUNOSUPPRESSIVE DRUG, BUT IT HAS NOT BEEN EXPLOITED FOR THIS PURPOSE. /VINBLASTINE SULFATE/

它在各数据库里的别名

vinblastine; 865-21-4; Vinblastin; Vincaleucoblastin; Vinblastina; Vincoblastine; Vincaleukoblastine; Nincaluicolflastine; Vinblastinum; Vincaleucoblastine; NCI-C04842; 5V9KLZ54CY; NSC 47842; NDC 0002-1452-01; NSC-47842; (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE

计算机算出的分子描述符

数据库摘要

Vinblastine sulfate · CAS 143-67-9 · C46H58N4O9. UNII 5V9KLZ54CY. 熔点: 267; 熔点: 211-216 °C; LogP: 3.7.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。