唑来膦酸

Description

Zoledronic acid · CAS 118072-93-8 · C5H10N2O7P2. UNII 70HZ18PH24. Solubility: 3.27e+00 g/L; LogP: -4.2.

Identification

CAS Registry Number	118072-93-8
PubChem CID	68740
Molecular formula	C5H10N2O7P2
IUPAC name	(1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid
UNII (FDA)	70HZ18PH24

Computed Descriptors

Molecular Weight	272.09
XLogP3	-4.3
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Exact Mass	271.99632466
Monoisotopic Mass	271.99632466
Topological Polar Surface Area	153
Heavy Atom Count	16
Formal Charge	0

Physical & Chemical Properties

Solubility	3.27e+00 g/L
LogP	-4.2

Physical description & handling notes

• Solid
• Sparingly soluble

GHS Hazard Classification

Reported hazard statements	H317 (100%), H319 (100%)

Documented Uses

• Consumption (g per capita) in the USA (2002): 2.03e-06
• For the treatment of hypercalcemia of malignancy. Also for the treatment of patients with multiple myeloma and patients with documented bone metastases from solid tumors, in conjunction with standard antineoplastic therapy. In May of 2007, the drug was approved for treatment of Paget's Disease.
• Zoledronic acid is indicated to treat hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors, osteoporosis in men and postmenopausal women, glucocorticoid induced osteoporosis, and Paget's disease of bone in men and women. Zoledronic acid is also indicated for the prevention of osteoporosis in post menopausal women and glucocorticoid induced osteoporosis.
• Zoledronate, also known as zoledronic acid, is an antiresorptive medication that belongs to a class of drugs known as bisphosphonates. Zoledronate is administered intravenously (IV) and is commonly prescribed and indicated to treat various metabolic bone disorders, including both malignant and benign diseases. As zoledronate is administered via the IV route, it can be utilized in patients with an intolerance or contraindication to oral bisphosphonates.
• Breast Feeding; Lactation; Bisphosphonates; Bone Density Conservation Agents; Diphosphonates;
• Medicines for endocrine disorders

Synonyms

Zoledronic acid; 118072-93-8; Zoledronate; Zometa; Reclast; Aclasta; (1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid; Zoledronic Acid Anhydrous; Anhydrous Zoledronic Acid; CGP 42446; DTXSID0042668; 70HZ18PH24; Phosphonic acid, [1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-; ZOL 446; (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid; NSC-721517

Frequently Asked Questions

What are the CAS number and molecular formula of Zoledronic acid?

CAS 118072-93-8; molecular formula C5H10N2O7P2; molecular weight — g/mol.

What other names is Zoledronic acid known by?

Zoledronic acid, 118072-93-8, Zoledronate, Zometa, Reclast, Aclasta.

Is Zoledronic acid classified as hazardous?

Hazard statements reported: H317, H319.

What are the key physical properties of Zoledronic acid?

Solubility: 3.27e+00 g/L; LogP: -4.2.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.