Oxolinic Acid

Description

Oxolinic Acid · CAS 14698-29-4 · C13H11NO5. UNII L0A22B22FT. Melting Point: 314-316 °C; LogP: 1.01; Collision Cross Section: 163.65 Ų [M+Na]+.

Identification

CAS Registry Number	14698-29-4
PubChem CID	4628
Molecular formula	C13H11NO5
IUPAC name	5-ethyl-8-oxo-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid
UNII (FDA)	L0A22B22FT

Computed Descriptors

Molecular Weight	261.23
XLogP3	-0.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	261.06372245
Monoisotopic Mass	261.06372245
Topological Polar Surface Area	76.1
Heavy Atom Count	19
Formal Charge	0

Physical & Chemical Properties

Melting Point	314-316 °C
LogP	1.01
Collision Cross Section	163.65 Ų [M+Na]+
Collision Cross Section	150.35 Ų [M+H]+

Physical description & handling notes

• CRYSTALS FROM DIMETHYLFORMAMIDE
• 152.6 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID1021089]
• 165.0 Ų [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID1021089]
• 152.3 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID1021089]
• 147.8 Ų [M+H]+ [CCS Type: TW]
• 167.2 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with Waters Major Mix]

Regulatory Status

Regulatory & Food Contact	ANTIMICROBIAL_AGENT: Veterinary Drug NO ADI ALLOCATED No ADI was established due to major deficiencies in the reporting and protocols of the available toxicity stud TRS 855-JECFA 43/36 OXOBOI URITRATE

GHS Hazard Classification

Reported hazard statements	H302 (98.9%), H332, H371, H373, H401, H411

Documented Uses

• Veterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes
• KAMINSKY, MELTZER, US PAT 3,287,458 (1966 TO WARNER-LAMBERT) EIDEM, J MED CHEM, 11, 160 (1968).
• Anti-Infective Agents, Quinolone; Anti-Infective Agents, Urinary
• DRUG HAS CHEMICAL STRUCTURE, MECHANISM OF ACTION, SPECTRUM OF ACTIVITY & POTENTIAL FOR TOXICITY THAT RESEMBLES NALIDIXIC ACID.
• OXOLINIC ACID IS ALTERNATIVE FORM OF THERAPY FOR PENICILLIN-SENSITIVE OR CEPHALOSPORIN-SENSITIVE ADULT WHO HAS RECURRENT URINARY TRACT INFECTION CAUSED BY SUSCEPTIBLE ESCHERICHIA COLI OR PROTEUS MIRABILIS THAT IS NOT COMPLICATED BY BACTEREMIA.
• ...EXERTS IN VITRO ACTIVITY AGAINST MOST GRAM-NEGATIVE AEROBIC BACILLI THAT CAUSE BACTERIAL URINARY TRACT INFECTIONS. MAJORITY OF ESCHERICHIA COLI, KLEBSIELLA SP, ENTEROBACTER SP & PROTEUS SP ARE SUSCEPTIBLE. ... SALMONELLA, SHIGELLA & NEISSERIA (MENINGITIDIS, GONORRHEAE) ARE SUSCEPTIBLE...STAPHYLOCOCCUS AUREUS...

Synonyms

oxolinic acid; 14698-29-4; Utibid; Prodoxal; Ossian; Pietil; Acido oxolinico; Acide oxolinique; Acidum oxolinicum; NSC-110364; W 4565; Aqualinic; 5-ethyl-8-oxo-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid; 5-Ethyl-8-oxo-5,8-dihydro[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid; 1-Ethyl-6,7-methylenedioxy-4-quinolone-3-carboxylic acid; DTXSID1021089

Frequently Asked Questions

What are the CAS number and molecular formula of Oxolinic Acid?

CAS 14698-29-4; molecular formula C13H11NO5; molecular weight — g/mol.

What other names is Oxolinic Acid known by?

oxolinic acid, 14698-29-4, Utibid, Prodoxal, Ossian, Pietil.

What is the regulatory status of Oxolinic Acid?

Documented regulatory listings: ANTIMICROBIAL_AGENT: Veterinary Drug; NO ADI ALLOCATED; No ADI was established due to major deficiencies in the reporting and protocols of the available toxicity stud.

Is Oxolinic Acid classified as hazardous?

Hazard statements reported: H302, H332, H371, H373, H401.

What are the key physical properties of Oxolinic Acid?

Melting Point: 314-316 °C; LogP: 1.01; Collision Cross Section: 163.65 Ų [M+Na]+; Collision Cross Section: 150.35 Ų [M+H]+.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.