盐酸乙丙嗪

Description

ethopropazine hydrochloride · CAS 1094-08-2 · C19H24N2S. UNII 7WI4P02YN1. Melting Point: 166-168; Melting Point: 64.5 °C; Solubility: 0.693.

Identification

CAS Registry Number	1094-08-2
PubChem CID	3290
Molecular formula	C19H24N2S
IUPAC name	N,N-diethyl-1-phenothiazin-10-ylpropan-2-amine
UNII (FDA)	7WI4P02YN1

Computed Descriptors

Molecular Weight	312.5
XLogP3	4.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	312.16601995
Monoisotopic Mass	312.16601995
Topological Polar Surface Area	31.8
Heavy Atom Count	22
Formal Charge	0

Physical & Chemical Properties

Melting Point	166-168
Melting Point	64.5 °C
Solubility	0.693
Solubility	5.24e-03 g/L
LogP	5.2
LogP	4.77

Physical description & handling notes

• Solid
• 174.37 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 167.61 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 172.03 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Documented Uses

• Profenamine is indicated in the symptomatic treatment of drug-induced extrapyramidal reactions and of the manifestations (rigidity, akinesia, sialorrhea, oculogyric crisis, tremor, etc.) of Parkinson's disease of encephalitic, arteriosclerotic or idiopathic origin. It is also used to control severe reactions to certain medicines such as reserpine.
• Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only.
• Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.
• Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.
• Well-absorbed from the gastrointestinal tract.

Synonyms

ethopropazine; Profenamine; Ethopromazine; 522-00-9; Profenaminum; Profenamina; 2-Diethylamino-1-propyl-N-dibenzoparathiazine; N,N-Diethyl-alpha-methyl-10H-phenothiazine-10-ethanamine; W-483; RP-3356; SC-2538; 7WI4P02YN1; (+-)-Ethopropazine; 10-[2-(Diethylamino)propyl]phenothiazine; 10-[2-(Diethylamino)-1-Propyl]phenothiazine; 10H-Phenothiazine-10-ethanamine, N,N-diethyl-alpha-methyl-

Frequently Asked Questions

What are the CAS number and molecular formula of ethopropazine hydrochloride?

CAS 1094-08-2; molecular formula C19H24N2S; molecular weight — g/mol.

What other names is ethopropazine hydrochloride known by?

ethopropazine, Profenamine, Ethopromazine, 522-00-9, Profenaminum, Profenamina.

What are the key physical properties of ethopropazine hydrochloride?

Melting Point: 166-168; Melting Point: 64.5 °C; Solubility: 0.693; Solubility: 5.24e-03 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.