Formoterol

Description

Formoterol · CAS 73573-87-2 · C19H24N2O4. UNII 5ZZ84GCW8B. Solubility: 4.16e-02 g/L; LogP: 2.2.

Identification

CAS Registry Number	73573-87-2
PubChem CID	3410
Molecular formula	C19H24N2O4
IUPAC name	N-[2-hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide
UNII (FDA)	5ZZ84GCW8B

Computed Descriptors

Molecular Weight	344.4
XLogP3	1.8
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	8
Exact Mass	344.17360725
Monoisotopic Mass	344.17360725
Topological Polar Surface Area	90.8
Heavy Atom Count	25
Formal Charge	0

Physical & Chemical Properties

Solubility	4.16e-02 g/L
LogP	2.2

Physical description & handling notes

• Solid
• Slightly (as fumarate salt)
• In water, 1.12X10+4 mg/L at 25 °C /Estimated/
• 5.0X10-14 mm Hg at 25 °C /Estimated/
• log Kow = 1.40 /Estimated/
• Henry's Law constant = 9.0X10-23 atm-cu m/mol at 25 °C /Estimated/

GHS Hazard Classification

Reported hazard statements	H332 (28.6%), H361 (71.4%), H362 (64.3%), H370 (28.6%), H372 (28.6%), H412 (35.7%)

Documented Uses

• Preparation: M. Murakami et al, DE 2305092; eidem, US 3994974 (1973, 1976 both to Yamanouchi)
• Information available in 2004 indicated that Formoterol was used in the manufacture of pharmaceutical preparations in the following countries: Austria, Belgium, Denmark, Greece, Ireland
• Information available in 2004 indicated that Formoterol hemifumerate was used in the manufacture of pharmaceutical preparations in the following countries: Austria, Brazil, Portugal, Singapore, Spain /Formoterol hemifumerate/
• Breast Feeding; Lactation; Milk, Human; Anti-Asthmatic Agents; Bronchodilator Agents; Beta Adrenergic Agonists
• Formoterol is indicated to treat asthma concomitantly with short-acting beta2-agonists, inhaled or systemic corticosteroids and theophylline therapy. /Included in US product labeling/
• Formoterol is indicated for long-term maintenance treatment of asthma in adult and children 5 years of age and older with reversible obstructive airway disease, including patients with symptoms of nocturnal asthma. /Included in US product labeling/

Synonyms

formoterol; 73573-87-2; Oxis; Formoterolum; N-[2-hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide; (+-)-Formoterol; 2'-hydroxy-5'-(1-hydroxy-2-((p-methoxy-alpha-methylphenethyl)amino)ethyl)formanilide; 2'-hydroxy-5'-{1-hydroxy-2-[(p-methoxy-alpha-methylphenethyl)amino]ethyl}formanilide; DTXSID1023077; N-(2-hydroxy-5-(1-hydroxy-2-(1-(4-methoxyphenyl)propan-2-ylamino)ethyl)phenyl)formamide; (+-)-2'-Hydroxy-5'-((RS)-1-hydroxy-2-(((RS)-p-methoxy-alpha-methylphenethyl)amino)ethyl)formanilide; RefChem:5843; CHEBI:5147; DTXCID4065311; R03AC13; 5ZZ84GCW8B

Frequently Asked Questions

What are the CAS number and molecular formula of Formoterol?

CAS 73573-87-2; molecular formula C19H24N2O4; molecular weight — g/mol.

What other names is Formoterol known by?

formoterol, 73573-87-2, Oxis, Formoterolum, N-[2-hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide, (+-)-Formoterol.

Is Formoterol classified as hazardous?

Hazard statements reported: H332, H361, H362, H370, H372.

What are the key physical properties of Formoterol?

Solubility: 4.16e-02 g/L; LogP: 2.2.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.