Flavopiridol

Description

Flavopiridol · CAS 146426-40-6 · C21H20ClNO5. UNII 45AD6X575G.

Identification

Computed Descriptors

Documented Uses

• Investigated for use/treatment in esophageal cancer, leukemia (lymphoid), lung cancer, liver cancer, and lymphoma (unspecified).
• Substances that inhibit or prevent the proliferation of NEOPLASMS.
• Endogenous or exogenous substances which inhibit the normal growth of human and animal cells or micro-organisms, as distinguished from those affecting plant growth (= PLANT GROWTH REGULATORS).
• Agents that inhibit PROTEIN KINASES.
• Flavopiridol has known human metabolites that include (2S,3S,4S,5R)-6-[2-(2-chlorophenyl)-5-hydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid.
• Inhibits cyclin-dependent kinases, arresting cell division and causing apoptosis in non-small lung cancer cells.

Synonyms

Flavopiridol; Alvocidib; 146426-40-6; Alvocidib freebase; L86-8275; L 868275; L-868275; alvocidibum; 2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one; HMR 1274; 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one; 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one; L 86-8275; 45AD6X575G; (-)cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one; CHEBI:47344

Frequently Asked Questions

What are the CAS number and molecular formula of Flavopiridol?

CAS 146426-40-6; molecular formula C21H20ClNO5; molecular weight — g/mol.

What other names is Flavopiridol known by?

Flavopiridol, Alvocidib, 146426-40-6, Alvocidib freebase, L86-8275, L 868275.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.