十六烷基磷酸胆碱

Description

hexadecylphosphocholine · CAS 58066-85-6 · C21H46NO4P. UNII 53EY29W7EC. Dissociation Constants: ~2.

Identification

CAS Registry Number	58066-85-6
PubChem CID	3599
Molecular formula	C21H46NO4P
IUPAC name	hexadecyl 2-(trimethylazaniumyl)ethyl phosphate
UNII (FDA)	53EY29W7EC

Computed Descriptors

Molecular Weight	407.6
XLogP3	6.7
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	20
Exact Mass	407.31644595
Monoisotopic Mass	407.31644595
Topological Polar Surface Area	58.6
Heavy Atom Count	27
Formal Charge	0

Physical & Chemical Properties

Dissociation Constants	~2

Physical description & handling notes

• Little is known about the clinical pharmacodynamics of miltefosine and other antileishmanial drugs.

GHS Hazard Classification

Reported hazard statements	H301 (100%), H319 (11.4%), H334 (84.8%), H361 (12.7%), H372 (11.4%)

Documented Uses

• For the treatment of mucosal (caused by Leishmania braziliensis), cutaneous (caused by L. braziliensis, L. guyanensis, and L. panamensis), and visceral leishmaniasis (caused by L. donovani). In comparing Leishmania drug susceptibility, it has been found that L. donovani is the most susceptible to miltefosine while L. major is the least susceptible. Off-label use includes treatment of free-living amebae (FLA) infections (unlabeled use; CDC, 2013).
• Miltefosine is an orally available, alkyl phospholipid that is used in the treatment of both cutaneous and visceral leishmaniasis. Miltefosine therapy is often accompanied by transient mild-to-moderate serum aminotransferase elevations during the first 1 or 2 weeks of treatment, but has not been implicated in cases of clinically apparent liver injury with jaundice.
• (1) Visceral leishmaniasis; (2) Mucocutaneous leishmaniasis; (3) Cutaneous leishmaniasis
• Miltefosine is an antiprotozoal prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of leishmaniasis.
• Leishmaniasis can be an opportunistic infection (OI) of HIV.
• Drink plenty of fluids. Preventing dehydration is important to prevent kidney injury.

Synonyms

Miltefosine; 58066-85-6; Hexadecylphosphocholine; Impavido; Miltex; HDPC; Hexadecylphosphorylcholine; Miltefosina; Miltefosinum; n-Hexadecylphosphorylcholine; hexadecyl 2-(trimethylazaniumyl)ethyl phosphate; D-18506; miltefosin; 53EY29W7EC; NSC-605583; DTXSID7045942

Frequently Asked Questions

What are the CAS number and molecular formula of hexadecylphosphocholine?

CAS 58066-85-6; molecular formula C21H46NO4P; molecular weight — g/mol.

What other names is hexadecylphosphocholine known by?

Miltefosine, 58066-85-6, Hexadecylphosphocholine, Impavido, Miltex, HDPC.

Is hexadecylphosphocholine classified as hazardous?

Hazard statements reported: H301, H319, H334, H361, H372.

What are the key physical properties of hexadecylphosphocholine?

Dissociation Constants: ~2.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.