Imipramine HCl

Description

Imipramine HCl · CAS 113-52-0 · C19H25ClN2. UNII BKE5Q1J60U.

Identification

Computed Descriptors

Physical description & handling notes

• >47.5 [ug/mL] (The mean of the results at pH 7.4)
• 165.1 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Documented Uses

• For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older. May also be used to manage panic disorders, with or without agoraphobia, as a second line agent in ADHD, management of eating disorders, for short-term management of acute depressive episodes in bipolar disorder and schizophrenia, and for symptomatic treatment of postherpetic neuralgia.
• 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, hydrochloride (1:1): ACTIVE
• Breast Feeding; Lactation; Milk, Human; Antidepressive Agents; Antidepressive Agents, Tricyclic
• Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However, the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.
• Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
• Exclusively metabolized by the liver. Imipramine is converted in the liver by various CYP isoenzymes (e.g. CYP1A2, CYP2D6, CYP3A4, CYP2C9) to active metabolites desipramine and 2-hydroxydesipramine. Route of Elimination: Approximately 40% of an orally administered dose is eliminated in urine within 24 hours, 70% in 72 hours. Small amounts are eliminated in feces via the biliary elimination. Half Life: Imipramine - 8-20 hours; Desipramine (active metabolite) - up to 125 hours

Synonyms

Imipramine hydrochloride; 113-52-0; Imipramine Hcl; Tofranil; Presamine; Pryleugan; Pramine; Antideprin hydrochloride; Imipramini hydrochloridum; DTXSID7040738; BKE5Q1J60U; NSC-114900; G-22355; 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, monohydrochloride; CHEBI:5882; DTXCID5020738

Frequently Asked Questions

What are the CAS number and molecular formula of Imipramine HCl?

CAS 113-52-0; molecular formula C19H25ClN2; molecular weight — g/mol.

What other names is Imipramine HCl known by?

Imipramine hydrochloride, 113-52-0, Imipramine Hcl, Tofranil, Presamine, Pryleugan.

Is Imipramine HCl classified as hazardous?

Hazard statements reported: H302.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.