Istradefylline

Description

Istradefylline · CAS 155270-99-8 · C20H24N4O4. UNII 2GZ0LIK7T4. Boiling Point: 601; Melting Point: 189-193; Solubility: 0.5µg/mL.

Identification

CAS Registry Number	155270-99-8
PubChem CID	5311037
Molecular formula	C20H24N4O4
IUPAC name	8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methylpurine-2,6-dione
UNII (FDA)	2GZ0LIK7T4

Computed Descriptors

Molecular Weight	384.4
XLogP3	2.5
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	384.17975526
Monoisotopic Mass	384.17975526
Topological Polar Surface Area	76.9
Heavy Atom Count	28
Formal Charge	0

Physical & Chemical Properties

Boiling Point	601
Melting Point	189-193
Solubility	0.5µg/mL
Dissociation Constants	0.78

Physical description & handling notes

• Istradefylline is a selective adenosine A_2A receptor inhibitor. It has a long duration of action as it is given once daily and has a half life of 64-69 hours. Patients taking this medication should be monitored for dyskinesia, hallucinations, and lack of impulse control. Consider dose reductions for these patients.

GHS Hazard Classification

Reported hazard statements	H301 (97.4%)

Documented Uses

• Istradefylline is indicated in adjunct to levodopa and carbidopa in the treatment of Parkinson's disease.
• Istradefylline is an adenosine receptor antagonist that is used as adjunctive therapy to levodopa/carbidopa in patients with Parkinson disease experiencing difficulty with “off” episodes when motor symptoms breakthrough on treatment. Istradefylline has been associated with a low rate of serum enzyme elevations during therapy, but has not been linked to cases of clinically apparent liver injury with jaundice.
• Avoid St. John's Wort. St. John's Wort decreases istradefylline concentrations.
• Take at the same time every day.
• Compounds that selectively bind to and block the activation of ADENOSINE A2 RECEPTORS.
• N04C - Other antiparkinson drugs

Synonyms

Istradefylline; 155270-99-8; KW-6002; nouriast; Nourianz; KW 6002; 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methylpurine-2,6-dione; istradefilina; DTXSID7057652; 2GZ0LIK7T4; (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione; DTXCID8031441; istradefyllinum; 8-((E)-2-(3,4-dimethoxyphenyl)ethenyl)-1,3-diethyl-7-methylpurine-2,6-dione; RefChem:57357; 8-(2-(3,4-dimethoxyphenyl)ethenyl)-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione

Frequently Asked Questions

What are the CAS number and molecular formula of Istradefylline?

CAS 155270-99-8; molecular formula C20H24N4O4; molecular weight — g/mol.

What other names is Istradefylline known by?

Istradefylline, 155270-99-8, KW-6002, nouriast, Nourianz, KW 6002.

Is Istradefylline classified as hazardous?

Hazard statements reported: H301.

What are the key physical properties of Istradefylline?

Boiling Point: 601; Melting Point: 189-193; Solubility: 0.5µg/mL; Dissociation Constants: 0.78.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.