Kanamycin base

Description

Kanamycin base · CAS 59-01-8 · C18H36N4O11. UNII EQK9Q303C5. Solubility: 9.23e+01 g/L; LogP: -6.3; Dissociation Constants: pKa = 7.2.

Identification

CAS Registry Number	59-01-8
PubChem CID	6032
Molecular formula	C18H36N4O11
IUPAC name	(2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol
UNII (FDA)	EQK9Q303C5

Computed Descriptors

Molecular Weight	484.5
XLogP3	-6.9
Hydrogen Bond Donor Count	11
Hydrogen Bond Acceptor Count	15
Rotatable Bond Count	6
Exact Mass	484.23805798
Monoisotopic Mass	484.23805798
Topological Polar Surface Area	283
Heavy Atom Count	33
Formal Charge	0

Physical & Chemical Properties

Solubility	9.23e+01 g/L
LogP	-6.3
Dissociation Constants	pKa = 7.2

Physical description & handling notes

• Solid
• Crystals from ethanol
• Crystals from methanol + ethanol
• Kanamycin sulfate is stable for 24 hours at room temperature in most iv infusion fluids including 0.9% sodium chloride or 5% dextrose injection.
• Crystals, MP 172-192 °C (decomposes). Specific optical rotation: +130 deg at 18 °C/D (c = 0.5 in water); +114 deg at 21 °C/D (c = 0.98 in water). Soluble in water, formamide; slightly soluble in chloroform, isopropyl alcohol. Practically insoluble in the common alcohols and nonpolar solvents. /Kanamycin B/
• Crystals from methanol + ethanol, decomposes above 270 °C. Specific optical rotation (H2O): +126 deg at 20 °C/D. Soluble in water, slightly soluble in formaldehyde. Practically insoluble in the common alcohols and nonpolar solvents. /Kanamycin C/

Regulatory Status

Regulatory & Food Contact	GROWTH_PROMOTER: Veterinary Drug NMRS 45/TRS 430-JECFA 12/16

Documented Uses

• Anti-Bacterial Agents; Protein Synthesis Inhibitors
• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• Veterinary Drug -> GROWTH_PROMOTER -> JECFA Functional Classes
• Antibiotic complex produced by Streptomyces kanamyceticus Okami and Umezawa from Japanese soil.
• D-Streptamine, O-3-amino-3-deoxy-.alpha.-D-glucopyranosyl-(1.fwdarw.6)-O-[6-amino-6-deoxy-.alpha.-D-glucopyranosyl-(1.fwdarw.4)]-2-deoxy-: ACTIVE

Synonyms

kanamycin; Kanamicina; Kanamycine; Kanamycinum; 8063-07-8; Kanamycins; Kanamycin Complex; RefChem:5930; RUC37XUP2P; CHEBI:6104; DTXSID2041171; CHEBI:24951; A07AA08; J01GB04; S01AA24; 200-411-7

Frequently Asked Questions

What are the CAS number and molecular formula of Kanamycin base?

CAS 59-01-8; molecular formula C18H36N4O11; molecular weight — g/mol.

What other names is Kanamycin base known by?

kanamycin, Kanamicina, Kanamycine, Kanamycinum, 8063-07-8, Kanamycins.

What is the regulatory status of Kanamycin base?

Documented regulatory listings: GROWTH_PROMOTER: Veterinary Drug; NMRS 45/TRS 430-JECFA 12/16.

What are the key physical properties of Kanamycin base?

Solubility: 9.23e+01 g/L; LogP: -6.3; Dissociation Constants: pKa = 7.2.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.