Lomustine

Description

Lomustine · CAS 13010-47-4 · C9H16ClN3O2. UNII 7BRF0Z81KG. Melting Point: 88-90 °C; Melting Point: 90 °C; Melting Point: 88 - 90 °C.

Identification

CAS Registry Number	13010-47-4
PubChem CID	3950
Molecular formula	C9H16ClN3O2
IUPAC name	1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
UNII (FDA)	7BRF0Z81KG

Computed Descriptors

Molecular Weight	233.69
XLogP3	2.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	233.0931045
Monoisotopic Mass	233.0931045
Topological Polar Surface Area	61.8
Heavy Atom Count	15
Formal Charge	0

Physical & Chemical Properties

Melting Point	88-90 °C
Melting Point	90 °C
Melting Point	88 - 90 °C
Solubility	111
Solubility	7.55e-01 g/L
LogP	2.83
LogP	log Kow = 2.83
LogP	2.8

Physical description & handling notes

• Solid
• Yellow powder
• Soluble in ethanol
• Freely soluble in chloroform; soluble in acetone.
• Solubility in water, 0.1N NaOH, 0.1N HCl, or 10% ethanol: <0.05 mg/mL; in absolute ethanol: 70 mg/mL
• Hazardous decomposition products formed under fire conditions: Carbon oxides, nitrogen oxides (NOx), hydrogen chloride gas.

GHS Hazard Classification

Reported hazard statements	H228 (34.4%), H242 (34.4%), H301 (100%), H340 (39.1%), H350 (100%), H360 (39.1%), H370 (35.9%), H372 (37.5%)

Documented Uses

• Nitrosourea used in the treatment of certain neoplastic diseases
• Medication to treat brain tumors, Hodgkin's disease, and other kinds of cancer
• For the treatment of primary and metastatic brain tumors as a component of combination chemotherapy in addition to appropriate surgical and/or radiotherapeutic procedures. Also used in combination with other agents as secondary therapy for the treatment of refractory or relapsed Hodgkin's disease.
• /Lomustine/ may be prepared by nitrosation of its substituted urea moiety, /1-(2-chloroethyl)-3-cyclohexylurea in a cold acid medium (e.g., formic acid)/.
• An alkylating agent of value against both hematologic malignancies and solid tumors.
• Lomustine is an orally administered alkylating agent used alone and in combination with other antineoplastic agents in the treatment of several malignancies including Hodgkin disease, lymphoma, and brain cancer. Lomustine therapy is associated with minor transient serum enzyme elevations and has been linked to rare cases of clinically apparent acute liver injury.

Synonyms

lomustine; 13010-47-4; 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea; Belustine; CeeNU; CCNU; Cecenu; CINU; Chloroethylcyclohexylnitrosourea; Lomustina; N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea; Urea, N-(2-chloroethyl)-N'-cyclohexyl-N-nitroso-; Lomustinum; NSC-79037; Gleostine; Cyclohexyl chloroethyl nitrosourea

Frequently Asked Questions

What are the CAS number and molecular formula of Lomustine?

CAS 13010-47-4; molecular formula C9H16ClN3O2; molecular weight — g/mol.

What other names is Lomustine known by?

lomustine, 13010-47-4, 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea, Belustine, CeeNU, CCNU.

Is Lomustine classified as hazardous?

Hazard statements reported: H228, H242, H301, H340, H350.

What are the key physical properties of Lomustine?

Melting Point: 88-90 °C; Melting Point: 90 °C; Melting Point: 88 - 90 °C; Solubility: 111.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.