lomefloxacin

Description

lomefloxacin · CAS 98079-51-7 · C17H19F2N3O3. UNII L6BR2WJD8V. Melting Point: 239-240.5 °C; Melting Point: 239 - 240.5 °C; Solubility: 27.2.

Identification

CAS Registry Number	98079-51-7
PubChem CID	3948
Molecular formula	C17H19F2N3O3
IUPAC name	1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
UNII (FDA)	L6BR2WJD8V

Computed Descriptors

Molecular Weight	351.35
XLogP3	-0.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	3
Exact Mass	351.13944780
Monoisotopic Mass	351.13944780
Topological Polar Surface Area	72.9
Heavy Atom Count	25
Formal Charge	0

Physical & Chemical Properties

Melting Point	239-240.5 °C
Melting Point	239 - 240.5 °C
Solubility	27.2
Solubility	1.06e-01 g/L
LogP	-0.3
LogP	2.8
Dissociation Constants	5.742

Physical description & handling notes

• Solid
• 191.3 Ų [M+H]+ [CCS Type: TW; Method: calibrated with Waters Major Mix]
• 196 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with Waters Major Mix]
• 191.04 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 172.69 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 190.34 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (100%), H312 (100%), H332 (100%)

Documented Uses

• For the treatment of bacterial infections of the respiratory tract (chronic bronchitis) and urinary tract, and as a pre-operative prophylactic to prevent urinary tract infection caused by: S.pneumoniae, H.influenzae, S.aureus, P.aeruginosa, E. cloacae, P. mirabilis, C. civersus, S. asprphyticus, E.coli, and K.pneumoniae.
• Breast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Antibacterial Agents; Quinolones; Fluoroquinolones
• Avoid multivalent ions. Separate the administration polyvalent ions, including magnesium and aluminum-containing antacids, from lomefloxacin by at least 4 hours before and 2 hours after lomefloxacin dosing.
• Take with or without food. The rate and extent of absorption may be reduced when lomefloxacin is taken with food.
• Substances that inhibit the growth or reproduction of BACTERIA.
• Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.

Synonyms

lomefloxacin; 98079-51-7; Lomefloxacine; Lomefloxacino; Lomefloxacinum; LFLX; 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; SC-47111A; L6BR2WJD8V; 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid; 1,4-Dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; DTXSID4040680; CHEBI:116278; (+-)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; Logiflox; Okacin

Frequently Asked Questions

What are the CAS number and molecular formula of lomefloxacin?

CAS 98079-51-7; molecular formula C17H19F2N3O3; molecular weight — g/mol.

What other names is lomefloxacin known by?

lomefloxacin, 98079-51-7, Lomefloxacine, Lomefloxacino, Lomefloxacinum, LFLX.

Is lomefloxacin classified as hazardous?

Hazard statements reported: H302, H312, H332.

What are the key physical properties of lomefloxacin?

Melting Point: 239-240.5 °C; Melting Point: 239 - 240.5 °C; Solubility: 27.2; Solubility: 1.06e-01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.