洛匹那韦

Description

Lopinavir · CAS 192725-17-0 · C37H48N4O5. UNII 2494G1JF75. Melting Point: 124-127 °C; Solubility: 1.92e-03 g/L.

Identification

CAS Registry Number	192725-17-0
PubChem CID	92727
Molecular formula	C37H48N4O5
IUPAC name	(2S)-N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
UNII (FDA)	2494G1JF75

Computed Descriptors

Molecular Weight	628.8
XLogP3	5.9
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	15
Exact Mass	628.36247064
Monoisotopic Mass	628.36247064
Topological Polar Surface Area	120
Heavy Atom Count	46
Formal Charge	0

Physical & Chemical Properties

Melting Point	124-127 °C
Solubility	1.92e-03 g/L

Physical description & handling notes

• Solid
• Colorless solid from ethyl acetone
• White to light tan powder
• Practically insoluble
• Practically insoluble in water
• Freely soluble in methanol and ethanol; soluble in isopropanol

Regulatory Status

GHS notification summary	1.6% (1 / 61)

GHS Hazard Classification

GHS notification summary	1.6% (1 / 61)
Reported hazard statements	H315 (88.5%), H319 (88.5%), H335 (88.5%), H373 (95.1%)

Documented Uses

• Anti-HIV Agents; HIV Protease Inhibitors
• Use (kg) in Switzerland (2009): >250
• Use (kg; approx.) in Germany (2009): >1000
• Consumption (g per capita) in Switzerland (2009): 0.032
• Consumption (g per capita; approx.) in Germany (2009): 0.012
• Consumption (g per capita) in the USA (2002): 0.033

Synonyms

Lopinavir; 192725-17-0; ABT-378; Aluviran; Koletra; A 157378.0; A-157378.0; Lopinavirum; DTXSID8046456; CHEBI:31781; A-157378-0; ABT378; Lopinavir, (s-(2s,4s,5s))-; 2494G1JF75; DTXCID6026456; RefChem:5960

Frequently Asked Questions

What are the CAS number and molecular formula of Lopinavir?

CAS 192725-17-0; molecular formula C37H48N4O5; molecular weight — g/mol.

What other names is Lopinavir known by?

Lopinavir, 192725-17-0, ABT-378, Aluviran, Koletra, A 157378.0.

Is Lopinavir classified as hazardous?

1.6% of GHS notifications report no hazard classification (1 of 61).

What are the key physical properties of Lopinavir?

Melting Point: 124-127 °C; Solubility: 1.92e-03 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.