甲磺酸乐伐替尼

Description

lenvatinib Mesylate · CAS 857890-39-2 · C22H23ClN4O7S. UNII 3J78384F61.

Identification

CAS Registry Number	857890-39-2
PubChem CID	11237762
Molecular formula	C22H23ClN4O7S
IUPAC name	4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxyquinoline-6-carboxamide;methanesulfonic acid
UNII (FDA)	3J78384F61

Computed Descriptors

Molecular Weight	523.0
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	6
Exact Mass	522.0975980
Monoisotopic Mass	522.0975980
Topological Polar Surface Area	178
Heavy Atom Count	35
Formal Charge	0
Complexity	727

GHS Hazard Classification

Reported hazard statements	H302 (25%), H360 (25%), H361 (50%), H362 (25%), H372 (50%), H373 (25%)

Documented Uses

• Lenvatinib mesylate is approved to be used alone or with other drugs to treat:
• • Endometrial carcinoma that is advanced and got worse after other systemic therapies. It is used with pembrolizumab in patients whose cancer is not microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) and cannot be treated with surgery or radiation therapy.
• • Hepatocellular carcinoma (a type of liver cancer). It is used as the first treatment in patients whose cancer cannot be removed by surgery.
• • Renal cell carcinoma (a type of kidney cancer) that is advanced. It is used:
• • With everolimus in adults who have received angiogenesis inhibitor therapy.
• • With pembrolizumab as the first treatment in adults.

Synonyms

LENVATINIB MESYLATE; 857890-39-2; Lenvatinib mesilate; E7080 MESYLATE; E-7080 MESYLATE; Lenvatinib methanesulfonate; 3J78384F61; CHEBI:85995; DTXSID90235081; N-(4-((6-Carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)-N'-cyclopropylurea monomethanesulfonate; RefChem:58937; DTXCID90157572; Multi-Kinase Inhibitor E7080 Mesylate; 4-(3-Chloro-4-(N'-cyclopropylureido)phenoxy)7-methoxyquinoline-6-carboxamide Mesylate; lenvatinibMesylate; Lenvima

Frequently Asked Questions

What are the CAS number and molecular formula of lenvatinib Mesylate?

CAS 857890-39-2; molecular formula C22H23ClN4O7S; molecular weight — g/mol.

What other names is lenvatinib Mesylate known by?

LENVATINIB MESYLATE, 857890-39-2, Lenvatinib mesilate, E7080 MESYLATE, E-7080 MESYLATE, Lenvatinib methanesulfonate.

Is lenvatinib Mesylate classified as hazardous?

Hazard statements reported: H302, H360, H361, H362, H372.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.