利那洛肽

Description

Linaclotide · CAS 851199-59-2 · C59H79N15O21S6. UNII N0TXR0XR5X.

Identification

CAS Registry Number	851199-59-2
PubChem CID	16158208
Molecular formula	C59H79N15O21S6
UNII (FDA)	N0TXR0XR5X

Computed Descriptors

Molecular Weight	1526.8
XLogP3	-6.8
Hydrogen Bond Donor Count	19
Hydrogen Bond Acceptor Count	28
Rotatable Bond Count	13
Exact Mass	1525.3899216
Monoisotopic Mass	1525.3899216
Topological Polar Surface Area	726
Heavy Atom Count	101
Formal Charge	0

Physical description & handling notes

• White to off-white powder
• Slightly soluble
• Slightly soluble in water
• Slightly soluble in aqueous sodium chloride
• Amorphous
• 14-amino acid peptide

GHS Hazard Classification

Reported hazard statements	H302 (100%)

Documented Uses

• Preparation: M. G. Currie, S. Mahajan-Miklos, World Intellectual Property Organization patent 04069165; idem et al., United States of America patent 7304036 (2004, 2007 both to Microbia).
• Linaclotide is small peptide agonist of guanylate cyclase C receptors in the intestine and is used orally as treatment of chronic constipation and irritable bowel syndrome. Linaclotide has not been linked to serum enzyme elevations during treatment or to episodes of clinically apparent liver injury.
• Breast Feeding; Lactation; Milk, Human; Gastrointestinal Agents; Peptides; Guanylate Cyclase C Agonists; Laxatives
• Linzess (linaclotide) is indicated in adults for the treatment of irritable bowel syndrome with constipation (IBS-C). /Included in US product label/
• Linzess is indicated in adults for the treatment of chronic idiopathic constipation (CIC). /Included in US product label/
• /BOXED WARNING/ WARNING: PEDIATRIC RISK. Linzess is contraindicated in pediatric patients up to 6 years of age; in nonclinical studies, administration of a single, clinically relevant adult oral dose of linaclotide caused deaths due to dehydration in young juvenile mice. Avoid use of Linzess in pediatric patients 6 through 17 years of age. The safety and efficacy of Linzess has not been established in pediatric patients under 18 years of age.

Synonyms

Linaclotide; Linzess; 851199-59-2; Constella; Linaclotida; N0TXR0XR5X; CHEBI:68551; ASP0456; DTXSID90234256; MD-1100; ASP-0456; MD-7246 (DELAYED RELEASE FORMULATION); linaclotidum; RefChem:57305; A06AX04; DTXCID90156747

Frequently Asked Questions

What are the CAS number and molecular formula of Linaclotide?

CAS 851199-59-2; molecular formula C59H79N15O21S6; molecular weight — g/mol.

What other names is Linaclotide known by?

Linaclotide, Linzess, 851199-59-2, Constella, Linaclotida, N0TXR0XR5X.

Is Linaclotide classified as hazardous?

Hazard statements reported: H302.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.