硫酸拉罗替尼

Description

Larotrectinib sulfate · CAS 1223405-08-0 · C21H24F2N6O6S. UNII RDF76R62ID.

Identification

CAS Registry Number	1223405-08-0
PubChem CID	67330085
Molecular formula	C21H24F2N6O6S
IUPAC name	(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide;sulfuric acid
UNII (FDA)	RDF76R62ID

Computed Descriptors

Molecular Weight	526.5
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	3
Exact Mass	526.14461000
Monoisotopic Mass	526.14461000
Topological Polar Surface Area	169
Heavy Atom Count	36
Formal Charge	0
Complexity	741

GHS Hazard Classification

Reported hazard statements	H302 (100%), H373 (100%)

Documented Uses

• Larotrectinib sulfate is approved to treat:
• • Solid tumors that have an NTRKgene fusion without a drug-resistancemutation in certain TRKproteins. It is used in adults and children whose cancer has spread to other parts of the body or cannot be removed by surgery and has gotten worse after other treatment or cannot be treated with other therapies.
• Larotrectinib sulfate is also being studied in the treatment of other types of cancer.

Synonyms

Larotrectinib sulfate; 1223405-08-0; LOXO-101 sulfate; ARRY-470 sulfate; RDF76R62ID; UNII-RDF76R62ID; LOXO 101 sulfate; ARRY 470 Sulfate; RefChem:57160; LOXO-101 (sulfate); Larotrectinib sulfate [USAN]; EX-A1981A; AC-30671; MS-29743; LAROTRECTINIB SULFATE [ORANGE BOOK]; D11138

Frequently Asked Questions

What are the CAS number and molecular formula of Larotrectinib sulfate?

CAS 1223405-08-0; molecular formula C21H24F2N6O6S; molecular weight — g/mol.

What other names is Larotrectinib sulfate known by?

Larotrectinib sulfate, 1223405-08-0, LOXO-101 sulfate, ARRY-470 sulfate, RDF76R62ID, UNII-RDF76R62ID.

Is Larotrectinib sulfate classified as hazardous?

Hazard statements reported: H302, H373.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.