洛替泼诺

Description

Loteprednol · CAS 129260-79-3 · C21H27ClO5. UNII Z8CBU6KR16. Melting Point: 220 - 224 °C; Solubility: 3.36e-02 g/L; LogP: 3.4.

Identification

CAS Registry Number	129260-79-3
PubChem CID	9865442
Molecular formula	C21H27ClO5
IUPAC name	chloromethyl (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate
UNII (FDA)	Z8CBU6KR16

Computed Descriptors

Molecular Weight	394.9
XLogP3	2.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	394.1547017
Monoisotopic Mass	394.1547017
Topological Polar Surface Area	83.8
Heavy Atom Count	27
Formal Charge	0

Physical & Chemical Properties

Melting Point	220 - 224 °C
Solubility	3.36e-02 g/L
LogP	3.4

Physical description & handling notes

• Solid

Documented Uses

• Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
• Established Pharmacologic Class [EPC] - Corticosteroid
• Mechanisms of Action [MoA] - Corticosteroid Hormone Receptor Agonists
• Loteprednol is a Corticosteroid. The mechanism of action of loteprednol is as a Corticosteroid Hormone Receptor Agonist.
• QS01B - Antiinflammatory agents
• QS01BA - Corticosteroids, plain

Synonyms

loteprednol; 129260-79-3; Z8CBU6KR16; CHEBI:50848; DTXSID10156128; Loteprednolum; RefChem:58138; DTXCID0078619; S01BA14; Loteprednol [INN:BAN]; UNII-Z8CBU6KR16; Loteprednol (INN); LOTEPREDNOL [INN]; chloromethyl 11beta,17alpha-dihydroxy-3-oxoandrosta-1,4-diene-17beta-carboxylate; Loteprednol Impurity 8; LOTEPREDNOL [VANDF]

Frequently Asked Questions

What are the CAS number and molecular formula of Loteprednol?

CAS 129260-79-3; molecular formula C21H27ClO5; molecular weight — g/mol.

What other names is Loteprednol known by?

loteprednol, 129260-79-3, Z8CBU6KR16, CHEBI:50848, DTXSID10156128, Loteprednolum.

What are the key physical properties of Loteprednol?

Melting Point: 220 - 224 °C; Solubility: 3.36e-02 g/L; LogP: 3.4.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.