L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-

Description

L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl- · CAS 736992-21-5 · C32H49N9O5. UNII 87GWG91S09.

Identification

Computed Descriptors

Documented Uses

• Under accelerated approval in the US, elamipretide is indicated to improve muscle strength in adult and pediatric patients with Barth syndrome weighing at least 30 kg.
• Elamipretide exposure increases proportionally over a dose range of 2 to 80 mg following daily subcutaneous injections with minimal accumulation. Maximum elamipretide concentrations were reached between 0.5 to 1 hour after subcutaneous administration. The absolute bioavailability following subcutaneous administration is approximately 92%. Elamipretide exposure is comparable after subcutaneous injection to the thigh or to the abdomen.
• Elamipretide and its metabolites M1 and M2 are excreted in the urine. At 48 hours post-dose, approximately 100% of the elamipretide dose was recovered in the urine as either elamipretide, M1, or M2 in patients with normal renal function.
• Elamipretide is distributed throughout total body water with an approximate volume of distribution of 0.5 L/kg.
• Protein binding is approximately 39%.
• Elamipretide is metabolized via sequential C-terminal degradation to the M1 tripeptide and M2 dipeptide metabolites, which do not have pharmacological activity. The metabolic pathways have not been fully characterized.

Synonyms

Elamipretide; 736992-21-5; bendavia; Ocuvia; MTP-131; MTP 131; SS-31; Szeto-schiller peptide; Elamipretida; MTP131; Nh2-d-arg-dmt-lys-phe-nh2; RX 31; SS 31; 87GWG91S09; RX-31; elamipretidum

Frequently Asked Questions

What are the CAS number and molecular formula of L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-?

CAS 736992-21-5; molecular formula C32H49N9O5; molecular weight — g/mol.

What other names is L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl- known by?

Elamipretide, 736992-21-5, bendavia, Ocuvia, MTP-131, MTP 131.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.