洛沙平

Name: 洛沙平
Brand: 济南圣和化工有限公司

CAS 1977-10-2C18H18ClN3OMW 327.8

洛沙平，CAS 登记号 1977-10-2，由济南圣和化工有限公司现货供应，可提供纯度按批次COA提供(不公开发布) 的规格，下游主要用于有机化学品。支持样品与小批量试用，批量价格请联系我们获取，验收以批次 COA 为准。

规格参数

CAS号1977-10-2

分子式C18H18ClN3O

分子量327.8

熔点109-111 °C

LogP3.6

纯度按批次COA提供(不公开发布)

包装按订单/批次确认(不公开发布)

应用领域有机化学品

类别有机化学品

用途与场景

有机化学品

包装与供货

包装规格按订单/批次确认(不公开发布)

纯度规格按批次COA提供(不公开发布)

储存条件密封、阴凉干燥处保存

供货周期现货/按订单安排

文件与支持

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本页已列出洛沙平的 CAS 号：1977-10-2，可与随货 COA 核对。

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主要涉及有机化学品。

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PubChem 公开数据

Description

loxapine · CAS 1977-10-2 · C18H18ClN3O. UNII LER583670J. Melting Point: 109-111 °C; Melting Point: 109-110 °C; Melting Point: 109 - 110 °C.

Identification

CAS Registry Number	1977-10-2
PubChem CID	3964
Molecular formula	C18H18ClN3O
IUPAC name	8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine
UNII (FDA)	LER583670J

Computed Descriptors

Molecular Weight	327.8
XLogP3	3.1
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Exact Mass	327.1138399
Monoisotopic Mass	327.1138399
Topological Polar Surface Area	28.1
Heavy Atom Count	23
Formal Charge	0

Physical & Chemical Properties

Melting Point	109-111 °C
Melting Point	109-110 °C
Melting Point	109 - 110 °C
Solubility	1.03e-01 g/L
LogP	3.6
LogP	3.86
Dissociation Constants	7.48
Dissociation Constants	7.5

Physical description & handling notes

Solid
Pale yellowish crystals from petroleum ether
When heated to decomposition it emits very toxic fumes of /hydrogen chloride/ and nitroxides.
175.7 Å² [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]
178.56 Å² [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
174.44 Å² [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H301 (100%)

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)

Documented Uses

For the management of the manifestations of psychotic disorders such as schizophrenia
Netherlands patent application 6,406,089 corresponds to Schmutz et al, US patent 3,546,226 (1964, 1970 both to Wander); Eidem, Helv Chim Acta 50, 245 (1967); Coppola, US patent 3,412,193 (1968 to American Cyanamid).
Loxapine is a conventional antipsychotic used in the therapy of schizophrenia. Loxapine therapy is commonly associated with minor serum aminotransferase elevations and in very rare instances has been linked to clinically apparent acute liver injury.
Breast Feeding; Lactation; Antipsychotic Agents
Loxapine (Class: Other Substances, Added Date: 07-2000)
Antipsychotic Agents; Dopamine Antagonists

Synonyms

loxapine; 1977-10-2; Cloxazepine; Oxilapine; Loxapin; Adasuve; Loxapina; Loxapinum; Hydrofluoride 3170; CL-62362; SUM 3170; SUM-3170; HF 3170; LW 3170; Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-; CL 62362

Frequently Asked Questions

What are the CAS number and molecular formula of loxapine?

CAS 1977-10-2; molecular formula C18H18ClN3O; molecular weight — g/mol.

What other names is loxapine known by?

loxapine, 1977-10-2, Cloxazepine, Oxilapine, Loxapin, Adasuve.

Is loxapine classified as hazardous?

Hazard statements reported: H301.

What are the key physical properties of loxapine?

Melting Point: 109-111 °C; Melting Point: 109-110 °C; Melting Point: 109 - 110 °C; Solubility: 1.03e-01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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