LDE-225 二磷酸盐

LDE-225 二磷酸盐（CAS 1218778-77-8）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

物理形态与操作说明

• Sonidegib has been shown to inhibit a transmembrane protein called SMO which plays a role in Hh signal transduction. This has resulted in inhibition of Hh signaling as well as antitumour activity in various animal models. In a transgenic mouse model of islet cell neoplasms, tumour volume was reduce by 95% in mice treated with sonidegib when compared with untreated mice. (2)

这个物质在各数据库里的编号

数据库记载的用途

• Sonidegib is approved for use in the US and EU for treatment of adults with locally advanced basal cell carcinoma (BCC) that has recurred post surgery or radiation therapy. It is also approved for adult patients with BCC who are not eligible for surgery or radiation therapy. (2)
• Sonidegib is a small molecule kinase inhibitor that blocks signaling in the hedgehog pathway and is used in the therapy of unresectable or metastatic basal cell carcinoma. Sonidegib therapy is associated with a low rate or transient serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Antineoplastic Agents; Enzyme Inhibitors; Hedgehog Pathway Inhibitors; Signal Transduction Inhibitors;
• Sonidegib is approved to treat:
• • Basal cell carcinoma that is locally advanced. It is used in adults whose disease has recurred (come back) after surgery or radiation therapy or who cannot be treated with surgery or radiation therapy.
• Sonidegib is also being studied in the treatment of other types of cancer.

它在各数据库里的别名

Erismodegib; Sonidegib; 956697-53-3; LDE225; NVP-LDE225; LDE-225; LDE 225; NVP-LDE 225; sonidegibum; 0RLU3VTK5M; NVP-LDE-225; CHEBI:90863; DTXSID501009335; N-(6-((cis-2,6-Dimethylmorpholin-4-yl)-3-pyridyl)-2-methyl-3-(4-(trifluoromethoxy)phenyl)benzamide; N-(6-((2R,6S)-2,6-Dimethylmorpholin-4-yl)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide; N-[6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide

计算机算出的分子描述符

数据库摘要

LDE-225 Diphosphate · CAS 1218778-77-8 · C26H26F3N3O3. UNII 0RLU3VTK5M.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。