糠酸莫米松

Description

Mometasone Furoate · CAS 83919-23-7 · C27H30Cl2O6. UNII 04201GDN4R. Melting Point: 215-228; LogP: 4.115.

Identification

CAS Registry Number	83919-23-7
PubChem CID	441336
Molecular formula	C27H30Cl2O6
IUPAC name	[(8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] furan-2-carboxylate
UNII (FDA)	04201GDN4R

Computed Descriptors

Molecular Weight	521.4
XLogP3	3.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	520.1419441
Monoisotopic Mass	520.1419441
Topological Polar Surface Area	93.8
Heavy Atom Count	35
Formal Charge	0

Physical & Chemical Properties

Melting Point	215-228
LogP	4.115

Physical description & handling notes

• Insoluble
• Mometasone is a synthetic corticosteroid with an affinity for glucocorticoid receptors 22 times higher than that of [dexamethasone]. Mometasone furoate also has a lower affinity to mineralocorticoid receptors than natural corticosteroids, making it more selective in its action. Mometasone furoate diffuses across cell membranes to activate pathways responsible for reducing inflammation.

GHS Hazard Classification

Reported hazard statements	H360 (94.3%), H370 (50%), H372 (55.7%), H373 (27.1%), H410 (27.9%)

Documented Uses

• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• Inhaled mometasone furoate is indicated for prophylaxis of asthma in patients ≥4 years. Applied topically as an ointment, mometasone furoate is indicated for symptomatic treatment of dermatitis and pruritis in patients ≥2 years. Mometasone furoate nasal spray is available both over-the-counter (OTC) and by prescription. The OTC nasal spray formulation of mometasone furoate is indicated for the treatment of upper respiratory allergic symptoms (e.g. rhinorrhea, sneezing) in patients ≥2 years of age. The prescription
• Substances that reduce or suppress INFLAMMATION.
• Drugs used to treat or prevent skin disorders or for the routine care of skin.
• Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
• Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]

Synonyms

mometasone furoate; 83919-23-7; Asmanex; Elocon; Sinuva; Asmanex HFA; Asmanex Twisthaler; Sch 32088; Mometasone furoate anhydrous; Sch-32088; DTXSID4023333; NSC-746171; LYR210; LYR-210; 04201GDN4R; NSC-760077

Frequently Asked Questions

What are the CAS number and molecular formula of Mometasone Furoate?

CAS 83919-23-7; molecular formula C27H30Cl2O6; molecular weight — g/mol.

What other names is Mometasone Furoate known by?

mometasone furoate, 83919-23-7, Asmanex, Elocon, Sinuva, Asmanex HFA.

Is Mometasone Furoate classified as hazardous?

Hazard statements reported: H360, H370, H372, H373, H410.

What are the key physical properties of Mometasone Furoate?

Melting Point: 215-228; LogP: 4.115.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.