Metoprolol

Description

Metoprolol · CAS 37350-58-6 · C15H25NO3. UNII GEB06NHM23. Melting Point: 120; LogP: 2.15; LogP: log Kow = 1.88.

Identification

CAS Registry Number	37350-58-6
PubChem CID	4171
Molecular formula	C15H25NO3
IUPAC name	1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
UNII (FDA)	GEB06NHM23

Computed Descriptors

Molecular Weight	267.36
XLogP3	1.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	9
Exact Mass	267.18344366
Monoisotopic Mass	267.18344366
Topological Polar Surface Area	50.7
Heavy Atom Count	19
Formal Charge	0

Physical & Chemical Properties

Melting Point	120
LogP	2.15
LogP	log Kow = 1.88
LogP	1.88
LogP	1.65
Dissociation Constants	9.56
Dissociation Constants	9.7
Collision Cross Section	172.54 Ų [M+H]+

Physical description & handling notes

• Solid
• 398ºC (estimate)
• Soluble (tartrate form)
• Solubility (mg/ml) @ 25 °C: water >1000; methanol >500; chloroform 496; acetone 1.1; acetonitrile 0.89; hexane 0.001; UV max (water): 223 nm (E 23400) /Tartrate/
• 172.1 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID2023309]
• 164.0 Ų [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID2023309]

Regulatory Status

GHS notification summary	33.3% (1 / 3)

GHS Hazard Classification

GHS notification summary	33.3% (1 / 3)
Reported hazard statements	H315 (66.7%), H319 (66.7%), H335 (66.7%), H411 (33.3%), H228 (33.3%), H302 (66.7%), H332 (33.3%), H361 (33.3%)

Documented Uses

• Use (kg) in Switzerland (2009): >2500
• Use (kg; approx.) in Germany (2009): >100000
• Use (kg; exact) in Germany (2009): 153125
• Use (kg) in France (2004): 8786
• Consumption (g per capita) in Switzerland (2009): 0.32
• Consumption (g per capita; approx.) in Germany (2009): 1.2

Synonyms

metoprolol; 51384-51-1; (RS)-Metoprolol; Beatrolol; dl-Metoprolol; Seroken; 37350-58-6; Metoprololum; Spesikor; 1-(Isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol; CGP 2175; CGP-2175; Metoprolol slow release; DTXSID2023309; GEB06NHM23; 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol

Frequently Asked Questions

What are the CAS number and molecular formula of Metoprolol?

CAS 37350-58-6; molecular formula C15H25NO3; molecular weight — g/mol.

What other names is Metoprolol known by?

metoprolol, 51384-51-1, (RS)-Metoprolol, Beatrolol, dl-Metoprolol, Seroken.

Is Metoprolol classified as hazardous?

33.3% of GHS notifications report no hazard classification (1 of 3).

What are the key physical properties of Metoprolol?

Melting Point: 120; LogP: 2.15; LogP: log Kow = 1.88; LogP: 1.88.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.