厚朴酚

Description

Magnolol · CAS 528-43-8 · C18H18O2. UNII 001E35HGVF. Melting Point: 101.5-102 °C.

Identification

CAS Registry Number	528-43-8
PubChem CID	72300
Molecular formula	C18H18O2
IUPAC name	2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol
UNII (FDA)	001E35HGVF
FEMA number	4559
JECFA number	2023

Computed Descriptors

Molecular Weight	266.3
XLogP3	5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	266.130679813
Monoisotopic Mass	266.130679813
Topological Polar Surface Area	40.5
Heavy Atom Count	20
Formal Charge	0

Physical & Chemical Properties

Melting Point	101.5-102 °C

Physical description & handling notes

• White powder; Bitter aroma
• Slightly soluble in water; soluble in DMSO
• Sparingly soluble (in ethanol)
• When heated to decomposition it emits acrid smoke and irritating vapors.

Regulatory Status

Regulatory & Food Contact	FDA Substance added to food: FLAVORING AGENT OR ADJUVANT FLAVOURING_AGENT: Flavouring Agent Flavoring Agents No safety concern at current levels of intake when used as a flavouring agent TRS 960-JECFA 73/114 FAS 64-JECFA 73/207

GHS Hazard Classification

Reported hazard statements	H315 (100%), H318 (64.9%), H319 (35.1%), H335 (64.9%), H411 (64.9%)

Documented Uses

• Magnolol and honokiol, biphenyl compounds, were isolated as anti-emetic principles from the methanolic extract of Magnolia obovata bark.
• Magnolia bark extract (MBE) is an extract of the dried stem, root, or branch bark of magnolia trees that has been used historically in traditional Chinese and Japanese medicines, and more recently as a component of dietary supplements and cosmetic products. /Magnolia bark extract/
• Magnolia officinalis is a commonly used traditional Chinese medicine for treating gastrointestinal disorders.
• Saiboku-To, a mixture of ten different herbal extracts, has been used in Japan and Czechoslovakia for corticosteroid-dependent severe asthma to reduce the maintenance doses of corticosteroid. Magnolol has been considered to be an active component of Saiboku-To.
• Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes
• Flavoring Agents -> JECFA Flavorings Index

Synonyms

Magnolol; 528-43-8; 5,5'-Diallyl-2,2'-dihydroxybiphenyl; Dehydrodichavicol; 2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol; 4-allyl-2-(5-allyl-2-hydroxy-phenyl)phenol; 001E35HGVF; DTXSID0044076; NSC-293099; FEMA NO. 4559; (1,1'-Biphenyl)-2,2'-diol, 5,5'-di-2-propenyl-; [1,1'-Biphenyl]-2,2'-diol, 5,5'-di-2-propenyl-; RefChem:155298; DTXCID8024076; 610-903-7; 5,5'-Diallyl-[1,1'-biphenyl]-2,2'-diol

Frequently Asked Questions

What are the CAS number and molecular formula of Magnolol?

CAS 528-43-8; molecular formula C18H18O2; molecular weight — g/mol.

What other names is Magnolol known by?

Magnolol, 528-43-8, 5,5'-Diallyl-2,2'-dihydroxybiphenyl, Dehydrodichavicol, 2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol, 4-allyl-2-(5-allyl-2-hydroxy-phenyl)phenol.

What is the regulatory status of Magnolol?

Documented regulatory listings: FDA Substance added to food: FLAVORING AGENT OR ADJUVANT; FLAVOURING_AGENT: Flavouring Agent; Flavoring Agents.

Is Magnolol classified as hazardous?

Hazard statements reported: H315, H318, H319, H335, H411.

What are the key physical properties of Magnolol?

Melting Point: 101.5-102 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.