盐酸马普替林

Description

maprotiline hydrochloride · CAS 10347-81-6 · C20H24ClN. UNII 7C8J54PVFI.

Identification

CAS Registry Number	10347-81-6
PubChem CID	71478
Molecular formula	C20H24ClN
IUPAC name	N-methyl-3-(1-tetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaenyl)propan-1-amine;hydrochloride
UNII (FDA)	7C8J54PVFI

Computed Descriptors

Molecular Weight	313.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	4
Exact Mass	313.1597275
Monoisotopic Mass	313.1597275
Topological Polar Surface Area	12
Heavy Atom Count	22
Formal Charge	0
Complexity	339

Physical description & handling notes

• >47.1 [ug/mL] (The mean of the results at pH 7.4)
• 45.8 [ug/mL] (The mean of the results at pH 7.4)
• 163.5 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

GHS notification summary	2.3% (1 / 43)

GHS Hazard Classification

GHS notification summary	2.3% (1 / 43)
Reported hazard statements	H302 (97.7%)

Documented Uses

• For treatment of depression, including the depressed phase of bipolar depression, psychotic depression, and involutional melancholia, and may also be helpful in treating certain patients suffering severe depressive neurosis.
• A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake.
• Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.

Synonyms

Maprotiline hydrochloride; 10347-81-6; Maprotiline Hcl; Ludiomil; 9-(gamma-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene hydrochloride; DTXSID2044507; 7C8J54PVFI; NSC-757085; 9,10-Ethanoanthracene-9(10H)-propanamine, N-methyl-, hydrochloride; BA-34276 HYDROCHLORIDE; Ba-34,276; N-Methyl-9,10-ethanoanthracene-9(10H)-propylamine hydrochloride; BA-34276; DTXCID0024507; 1-(3-Methylaminopropyl)dibenzo(b,e)bicyclo(2.2.2)octadiene hydrochloride; RefChem:57782

Frequently Asked Questions

What are the CAS number and molecular formula of maprotiline hydrochloride?

CAS 10347-81-6; molecular formula C20H24ClN; molecular weight — g/mol.

What other names is maprotiline hydrochloride known by?

Maprotiline hydrochloride, 10347-81-6, Maprotiline Hcl, Ludiomil, 9-(gamma-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene hydrochloride, DTXSID2044507.

Is maprotiline hydrochloride classified as hazardous?

2.3% of GHS notifications report no hazard classification (1 of 43).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.