nimodipine

Description

nimodipine · CAS 66085-59-4 · C21H26N2O7. UNII 57WA9QZ5WH. Melting Point: 125; Melting Point: 125 °C; Solubility: 1.20e-02 g/L.

Identification

CAS Registry Number	66085-59-4
PubChem CID	4497
Molecular formula	C21H26N2O7
IUPAC name	3-O-(2-methoxyethyl) 5-O-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
UNII (FDA)	57WA9QZ5WH

Computed Descriptors

Molecular Weight	418.4
XLogP3	3.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	9
Exact Mass	418.17400117
Monoisotopic Mass	418.17400117
Topological Polar Surface Area	120
Heavy Atom Count	30
Formal Charge	0

Physical & Chemical Properties

Melting Point	125
Melting Point	125 °C
Solubility	1.20e-02 g/L
LogP	3.05
LogP	2.7
LogP	2.82

Physical description & handling notes

• Solid
• 202.11 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 182.83 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 198.78 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 194.6 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 197.8 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]

Regulatory Status

GHS notification summary	1.5% (1 / 67)

GHS Hazard Classification

GHS notification summary	1.5% (1 / 67)
Reported hazard statements	H315 (35.8%), H361 (37.3%), H373 (58.2%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• For use as an adjunct to improve neurologic outcome following subarachnoid hemorrhage (SAH) from ruptured intracranial berry aneurysms by reducing the incidence and severity of ischemic deficits.
• Nimodipine (C21H26N2O7) is a second-generation 1,4-dihydropyridine calcium channel blocker initially developed to manage systemic hypertension. The FDA approved its use in 1988. However, its current use is restricted primarily to managing vasospasm following subarachnoid hemorrhage.
• Nimodipine is a second generation calcium channel blocker used in the treatment of cerebral vasospasm after subarachnoid hemorrhage. Nimodipine is not widely used and has not been implicated in causing clinically apparent acute liver injury.
• Breast Feeding; Lactation; Antihypertensive Agents; Calcium Channel Blockers; Vasodilator Agents

Synonyms

nimodipine; 66085-59-4; Nimotop; Periplum; Admon; Nimodipino; Nymalize; Nimodipinum; BAY e 9736; Bay-e-9736; nemotan; Nimodipine ap; DTXSID5023370; Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate; 57WA9QZ5WH; NSC-758476

Frequently Asked Questions

What are the CAS number and molecular formula of nimodipine?

CAS 66085-59-4; molecular formula C21H26N2O7; molecular weight — g/mol.

What other names is nimodipine known by?

nimodipine, 66085-59-4, Nimotop, Periplum, Admon, Nimodipino.

Is nimodipine classified as hazardous?

1.5% of GHS notifications report no hazard classification (1 of 67).

What are the key physical properties of nimodipine?

Melting Point: 125; Melting Point: 125 °C; Solubility: 1.20e-02 g/L; LogP: 3.05.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.