Nizatidine

Description

Nizatidine · CAS 76963-41-2 · C12H21N5O2S2. UNII P41PML4GHR. Melting Point: 130-132 °C; Solubility: 10-33mg/mL; LogP: 1.1.

Identification

CAS Registry Number	76963-41-2
PubChem CID	4513
Molecular formula	C12H21N5O2S2
IUPAC name	1-N'-[2-[[2-[(dimethylamino)methyl]-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine
UNII (FDA)	P41PML4GHR

Computed Descriptors

Molecular Weight	331.5
XLogP3	1.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	9
Exact Mass	331.11366728
Monoisotopic Mass	331.11366728
Topological Polar Surface Area	140
Heavy Atom Count	21
Formal Charge	0

Physical & Chemical Properties

Melting Point	130-132 °C
Solubility	10-33mg/mL
LogP	1.1

Physical description & handling notes

• Crystals from ethanol-ethyl acetate
• Off-white to buff crystalline solid
• Mild, sulfur-like odor
• Bitter
• Soluble in water
• 178.1 Ų [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID5023376]

GHS Hazard Classification

Reported hazard statements	H302 (97.6%)

Documented Uses

• RP Pioch, Eur Pat Appl 49618; Idem, US Pat 4,375547 (1982, 1983 both to Eli Lilly)
• For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, active benign gastric ulcer, and active duodenal ulcer.
• Nizatidine is a histamine type 2 receptor antagonist (H2 blocker) which is widely used for treatment of acid-peptic disease and heartburn. Nizatidine has been linked to rare instances of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Anti-Ulcer Agents; Histamine H2 Antagonists; Gastrointestinal Agents
• Nizatidine (Class: Other Substances, Added Date: 01-2001)
• Anti-Ulcer Agents; Histamine H2 Antagonists

Synonyms

Acinon; Nizatidina; Axid; Axid Ar; Nizatidinum; DTXSID5023376; P41PML4GHR; LY 139037; NSC-759289; 1,1-Ethenediamine, N-(2-(((2-((dimethylamino)methyl)-4-thiazolyl)methyl)thio)ethyl)-N'-methyl-2-nitro-; LY-139037; N-(2-(((2-((Dimethylamino)methyl)-4-thiazolyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine; N-(4-(6-Methylamino-7-nitro-2-thia-5-aza-6-hepten-1-yl)-2-thiazolylmethyl)-N,N-dimethylamin; CHEBI:7601; DTXCID403376; n-[2-[[[2-[(dimethylamino)methyl]-4-thiazolyl]methyl]thio]ethyl]-n'-methyl-2-nitro-1,1-ethenediamine

Frequently Asked Questions

What are the CAS number and molecular formula of Nizatidine?

CAS 76963-41-2; molecular formula C12H21N5O2S2; molecular weight — g/mol.

What other names is Nizatidine known by?

Acinon, Nizatidina, Axid, Axid Ar, Nizatidinum, DTXSID5023376.

Is Nizatidine classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of Nizatidine?

Melting Point: 130-132 °C; Solubility: 10-33mg/mL; LogP: 1.1.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.