尼索地平

Description

Nisoldipine · CAS 63675-72-9 · C20H24N2O6. UNII 4I8HAB65SZ. Solubility: 5.77e-03 g/L; LogP: 3.26; LogP: 3.1.

Identification

CAS Registry Number	63675-72-9
PubChem CID	4499
Molecular formula	C20H24N2O6
IUPAC name	3-O-methyl 5-O-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
UNII (FDA)	4I8HAB65SZ

Computed Descriptors

Molecular Weight	388.4
XLogP3	3.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Exact Mass	388.16343649
Monoisotopic Mass	388.16343649
Topological Polar Surface Area	110
Heavy Atom Count	28
Formal Charge	0

Physical & Chemical Properties

Solubility	5.77e-03 g/L
LogP	3.26
LogP	3.1
LogP	3.59

Physical description & handling notes

• Solid
• 195.5 Ų [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID0023371]
• 190.3 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 184.16 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 193.15 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 187.2 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (100%), H312 (60.9%), H361 (36.2%), H411 (34.8%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• For the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.
• Nisoldipine is a second generation calcium channel blocker and commonly used antihypertensive agent. Nisoldipine therapy is associated with a low rate of serum enzyme elevations, but has not been specifically linked to instances of clinical apparent acute liver injury.
• Breast Feeding; Lactation; Antihypertensive Agents; Calcium Channel Blockers; Vasodilator Agents;
• Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.

Synonyms

nisoldipine; 63675-72-9; Sular; Nisocor; Baymycard; Nisoldipin; Bay k 5552; Nisoldipino; Nisoldipinum; Bay-k-5552; Geomatrix 16e; DTXSID0023371; Nisoldipine (stn); Nisoldipine SR; 4I8HAB65SZ; NSC-759106

Frequently Asked Questions

What are the CAS number and molecular formula of Nisoldipine?

CAS 63675-72-9; molecular formula C20H24N2O6; molecular weight — g/mol.

What other names is Nisoldipine known by?

nisoldipine, 63675-72-9, Sular, Nisocor, Baymycard, Nisoldipin.

Is Nisoldipine classified as hazardous?

Hazard statements reported: H302, H312, H361, H411.

What are the key physical properties of Nisoldipine?

Solubility: 5.77e-03 g/L; LogP: 3.26; LogP: 3.1; LogP: 3.59.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.