Nebivolol

Description

Nebivolol · CAS 99200-09-6 · C22H25F2NO4. UNII 030Y90569U. Melting Point: 223.0-228.0; Solubility: 0.091g/100mL; Solubility: 4.03e-02 g/L.

Identification

CAS Registry Number	99200-09-6
PubChem CID	71301
Molecular formula	C22H25F2NO4
IUPAC name	1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]ethanol
UNII (FDA)	030Y90569U

Computed Descriptors

Molecular Weight	405.4
XLogP3	3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Exact Mass	405.17516460
Monoisotopic Mass	405.17516460
Topological Polar Surface Area	71
Heavy Atom Count	29
Formal Charge	0

Physical & Chemical Properties

Melting Point	223.0-228.0
Solubility	0.091g/100mL
Solubility	4.03e-02 g/L
LogP	4.183
LogP	2.76
Dissociation Constants	8.22
Dissociation Constants	8.13

Physical description & handling notes

• Solid

GHS Hazard Classification

Reported hazard statements	H302 (100%), H315 (50%), H319 (50%), H332 (50%), H335 (50%), H361 (50%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >750
• Consumption (g per capita; approx.) in Germany (2009): 0.00916
• Nebivolol is indicated to treat hypertension.
• Nebivolol is an FDA-approved medication used to treat hypertension. Beta-blockers are a class of agents used to treat multiple conditions, including hypertension, angina, arrhythmias, anxiety, hyperthyroidism, migraine prevention, and prevention of essential tremors. The American College of Cardiology (ACC)/American Heart Association (AHA) guidelines advise against using β-blockers as the first-line treatment for hypertension and to reserve them for patients with comorbidities such as ischemic heart disease.
• Nebivolol is a beta-blocker and antihypertensive medication that has additional vasodilatory activity mediated by nitric oxide release. Nebivolol has yet to be linked to instances of clinically apparent liver injury.
• Breast Feeding; Lactation; Milk, Human; Adrenergic beta-Antagonists; Antihypertensive Agents; Vasodilator Agents

Synonyms

Nebivolol; Narbivolol; 118457-14-0; R-65824; dl-Nebivolol; DTXSID9040556; R65,824; Nebivololum; nebibolol; Hypoloc; Hydrochloride, Nebivolol; RefChem:56585; alpha,alpha'-(iminobis(methylene))bis(6-fluoro-3,4-dihydro)-2H-1-benzopyran-2-methanol; DTXCID7020556; CHEBI:64022; C07AB12

Frequently Asked Questions

What are the CAS number and molecular formula of Nebivolol?

CAS 99200-09-6; molecular formula C22H25F2NO4; molecular weight — g/mol.

What other names is Nebivolol known by?

Nebivolol, Narbivolol, 118457-14-0, R-65824, dl-Nebivolol, DTXSID9040556.

Is Nebivolol classified as hazardous?

Hazard statements reported: H302, H315, H319, H332, H335.

What are the key physical properties of Nebivolol?

Melting Point: 223.0-228.0; Solubility: 0.091g/100mL; Solubility: 4.03e-02 g/L; LogP: 4.183.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.