nortriptyline

Description

nortriptyline · CAS 72-69-5 · C19H21N. UNII BL03SY4LXB. Boiling Point: 396.62; Melting Point: 58; Melting Point: 213 - 215 °C.

Identification

CAS Registry Number	72-69-5
PubChem CID	4543
Molecular formula	C19H21N
IUPAC name	N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine
UNII (FDA)	BL03SY4LXB

Computed Descriptors

Molecular Weight	263.4
XLogP3	4.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	3
Exact Mass	263.167399674
Monoisotopic Mass	263.167399674
Topological Polar Surface Area	12
Heavy Atom Count	20
Formal Charge	0

Physical & Chemical Properties

Boiling Point	396.62
Melting Point	58
Melting Point	213 - 215 °C
Solubility	0.00087
Solubility	8.74e-04 g/L
LogP	3.9
LogP	log Kow = 4.51
LogP	4.7
LogP	4.4
Dissociation Constants	10.13

Physical description & handling notes

• Solid
• Stable under recommended storage conditions. /Nortriptyline hydrochloride/
• When heated to decomposition it emits toxic fumes of /nitrogen oxides/.
• 164.8 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: Antidepressants]
• 165.77 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 160.77 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (100%)

Documented Uses

• Adrenergic Uptake Inhibitors; Antidepressive Agents, Tricyclic
• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• Consumption (g per capita) in the USA (2002): 0.0104
• For the treatment of depression, chronic pain, irritable bowel syndrome, sleep disorders, diabetic neuropathy, agitation and insomnia, and migraine prophylaxis.
• Pharmaceuticals -> Transformation products

Synonyms

nortriptyline; 72-69-5; Noramitriptyline; Desitriptilina; Ateben; Avantyl; Lumbeck; Desmethylamitriptyline; Noritren; Sensaval; Demethylamitriptyline; Sesaval; Demethylamitryptyline; Nortryptiline; Nortryptyline; Nortrilen

Frequently Asked Questions

What are the CAS number and molecular formula of nortriptyline?

CAS 72-69-5; molecular formula C19H21N; molecular weight — g/mol.

What other names is nortriptyline known by?

nortriptyline, 72-69-5, Noramitriptyline, Desitriptilina, Ateben, Avantyl.

Is nortriptyline classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of nortriptyline?

Boiling Point: 396.62; Melting Point: 58; Melting Point: 213 - 215 °C; Solubility: 0.00087.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.