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Nefazodone

CAS 83366-66-9C25H32ClN5O2MW 470.0

Nefazodone (CAS No. 83366-66-9) is supplied by Jinan Shenghe Chemical Co., Ltd. with a typical purity of 按批次COA提供(不公开发布). Main applications include Organic Chemicals. Bulk quantities are available with COA; purity and packaging are subject to batch COA and order confirmation.

Specifications

CAS Number83366-66-9
Molecular FormulaC25H32ClN5O2
Molecular Weight470.0
Melting Point83.5
LogP4.7
Purity按批次COA提供(不公开发布)
Packaging按订单/批次确认(不公开发布)
ApplicationsOrganic Chemicals
CategoryOrganic Chemicals

Where it is used

Organic Chemicals

Packaging & Supply

Packaging按订单/批次确认(不公开发布)
Purity按批次COA提供(不公开发布)
StorageSealed, cool and dry place
Lead TimeIn stock / per order

Documents & Support

COA provided with every batch; MSDS and technical documents available on request. Email us with product name and CAS number for a quote within one business day.

Frequently Asked Questions

What is the CAS number of Nefazodone?

The CAS number of Nefazodone is 83366-66-9.

What purity and packaging are available?

Typical purity is 按批次COA提供(不公开发布), supplied in 按订单/批次确认(不公开发布), with COA provided.

What are the applications of Nefazodone?

Main applications include Organic Chemicals.

How do I buy Nefazodone or get a quote?

Email info@591daili.com or reach us on WhatsApp with the product name, CAS number and required quantity; quotes within one business day. Supplier: Jinan Shenghe Chemical Co., Ltd..

PubChem Public Data

Description

Nefazodone · CAS 83366-66-9 · C25H32ClN5O2. UNII 59H4FCV1TF. Melting Point: 83.5; Melting Point: 83-84 °C; Melting Point: 83 - 84 °C.

Identification

CAS Registry Number83366-66-9
PubChem CID4449
Molecular formulaC25H32ClN5O2
IUPAC name2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3-one
UNII (FDA)59H4FCV1TF

Computed Descriptors

Molecular Weight470.0
XLogP34.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count10
Exact Mass469.2244530
Monoisotopic Mass469.2244530
Topological Polar Surface Area51.6
Heavy Atom Count33
Formal Charge0

Physical & Chemical Properties

Melting Point83.5
Melting Point83-84 °C
Melting Point83 - 84 °C
Solubility6.98e-02 g/L
LogP4.7
LogP4.95
Dissociation Constants6.5

Physical description & handling notes

  • Solid
  • Crystals from 2-propanol/heptane
  • Crystals from 2-propanol, with slow cooling yields a polymorph. MP: 186.0-187.0 °C. Also reported as crystals from ethanol. Nonhygroscopic. MP. 175-177 °C. Freely solluble in chloroform; soluble in propylene gylcol; slightly soluble in polyethylene glycol, water /Nefazodone hydrchloride/
  • 32.6 [ug/mL] (The mean of the results at pH 7.4)
  • Stable under recommended storage conditions. /Nefazodone hydrochloride/
  • 211.7 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]

Documented Uses

  • Antidepressive Agents, Second-Generation
  • Consumption (g per capita) in the USA (2002): 0.0826
  • Nefazodone (sold as Serzone, Nefadar) is a psychoactive drug and antidepressant. [wikipedia]
  • Preparation: D. L. Temple, Jr., W. G. Lobeck, Jr., United States of America patent 4338317 (1982 to Mead Johnson).
  • For the treatment of depression.
  • Nefazodone is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder. Nefazodone therapy has been associated with transient, usually asymptomatic elevations in serum aminotransferase levels and has been linked to several instances of clinically apparent acute liver injury some of which have been fatal.

Synonyms

nefazodone; 83366-66-9; Nefazodona; Nefazodonum; Nefazodonum [Latin]; 1-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-3-ethyl-4-(2-phenoxyethyl)-delta2-1,2,4-triazolin-5-one; 59H4FCV1TF; CHEBI:7494; 1-(3-(4-(3-Chlorpheyl-1-piperazinylpropyl)-3-ethyl-4,5-dihydro-4-(2-phenoxyethyl)-1,2,4-triazol-5-on; DTXSID2023357; Nefazodonum (Latin); 1-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one; 3H-1,2,4-Triazol-3-one, 2,4-dihydro-2-3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-ethyl-4-(2-phenoxyethyl)-; 1-(3-(4-(3-chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one; RefChem:57773; DTXCID203357

Frequently Asked Questions

What are the CAS number and molecular formula of Nefazodone?

CAS 83366-66-9; molecular formula C25H32ClN5O2; molecular weight — g/mol.

What other names is Nefazodone known by?

nefazodone, 83366-66-9, Nefazodona, Nefazodonum, Nefazodonum [Latin], 1-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-3-ethyl-4-(2-phenoxyethyl)-delta2-1,2,4-triazolin-5-one.

What are the key physical properties of Nefazodone?

Melting Point: 83.5; Melting Point: 83-84 °C; Melting Point: 83 - 84 °C; Solubility: 6.98e-02 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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