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Description

nordihydroguaiaretic acid · CAS 500-38-9 · C18H22O4.

Identification

CAS Registry Number	500-38-9
PubChem CID	4534
Molecular formula	C18H22O4
IUPAC name	4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol

Computed Descriptors

Molecular Weight	302.4
XLogP3	4.3
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	302.15180918
Monoisotopic Mass	302.15180918
Topological Polar Surface Area	80.9
Heavy Atom Count	22
Formal Charge	0

Physical description & handling notes

• Solid; [Merck Index] White odorless powder; [Alfa Aesar MSDS]
• 167.5 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID5022437]

Regulatory Status

Regulatory & Food Contact	FDA Substance added to food: ANTIOXIDANT FDA Inventory of Food Contact Substances Listed in 21 CFR: FCS ANTIOXIDANT: Food Additives NORDIHYDROGUAIARETIC ACID--PROHIBITED WITH EXCEPTIONS NO ADI ALLOCATED NMRS 53/TRS 539-JECFA 17/36

GHS Hazard Classification

Reported hazard statements	H302 (100%), H315 (99.5%), H319 (99.5%), H335 (95.2%)

Documented Uses

• Occurs in the creosote bush; Used as an antioxidant in foods and as an antineoplastic; [Merck Index]
• Banned for use as an antioxidant in food; [EPA]
• Food Additives -> ANTIOXIDANT -> JECFA Functional Classes

Synonyms

nordihydroguaretic acid; 2,3-bis(3,4-dihydroxybenzyl)butane; RefChem:854717; NORDIHYDROGUAIARETIC ACID; 500-38-9; NDGA; 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol; Norhydroguaiaretic acid; Norguaiaretic acid, dihydro-; 1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-; NSC 4291; 4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol; MFCD00002206; 2,3-Bis(3,4-dihydroxyphenylmethyl)butane; DTXSID5022437; Pyrocatechol, 4,4'-(2,3-dimethyltetramethylene)di-

Frequently Asked Questions

What are the CAS number and molecular formula of nordihydroguaiaretic acid?

CAS 500-38-9; molecular formula C18H22O4; molecular weight — g/mol.

What other names is nordihydroguaiaretic acid known by?

nordihydroguaretic acid, 2,3-bis(3,4-dihydroxybenzyl)butane, RefChem:854717, NORDIHYDROGUAIARETIC ACID, 500-38-9, NDGA.

What is the regulatory status of nordihydroguaiaretic acid?

Documented regulatory listings: FDA Substance added to food: ANTIOXIDANT; FDA Inventory of Food Contact Substances Listed in 21 CFR: FCS; ANTIOXIDANT: Food Additives.

Is nordihydroguaiaretic acid classified as hazardous?

Hazard statements reported: H302, H315, H319, H335.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.